Blood lead, calcium and phosphorus in women with preeclampsia in Edo State, Nigeria
Date
2012
Authors
Ikaraoha, CI
Oforofuo, IOA
Anetor, JI
Okogbo, FO
Okogbenin, SA
Alonge, TO
Mbadiwe, NC
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
ABSTRACT. The authors investigated the effect of blood lead (BPb) and its relationship with calcium
and phosphorus in the development of preeclampsia in Nigeria. Blood samples were collected from
59 preclamptics, 150 normal pregnant, and 122 nonpregnant women. Blood lead and serum Ca and
P were determined. Blood lead was significantly higher (p < .001), whereas serum Ca and P were
significantly lower (p < .001) in preclamptics than in normal pregnant women (60.2 12.8 vs 26.3
8.0 μg/dL for Pb, 1.39 0.33 vs 2.03 0.22 mmol/L for Ca, and 0.76 0.10 vs 0.99 0.13 mmol/L
for P, respectively). There was significant increase (p < .05) in BPb and decreases (p < .01) in serum
Ca and P in pregnant women than in nonpregnant women (35.7 18.0 vs 13.1 6.4 μg/dL for Pb,
1.85 0.33 vs 2.33 0.20 mmol/L for Ca, and 0.93 0.38 vs 1.24 0.26 mmol/L for P). Also, BPb
was negatively correlated with serum Ca and, P, and positively correlated with systolic and diastolic
blood pressures in pregnancy (r =−.804 for Ca, r =−.728 for P, r = .908 for SBP, and r = .842 for
DBP) and preeclampsia (p < .01). It appears that increase in blood lead, which parallels decreases in
serum calcium and phosphorus, may be related to the development and progression of preeclampsia
in this environment.
Description
Scholarly article
Keywords
calcium , lead , phosphorus , preeclampsia , pregnancy , Research Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseases
Citation
Ikaraoha CI, Oforofuo IAO, Anetor JI, Okogbo FO, Okusanya BO, Okogbenin SA, Alonge TO, Mbadiwe NC. Blood lead, calcium and phosphorus in women with preeclampsia in Edo State, Nigeria. Arch Environ Occup Health. 2012; 67 (3):163-169