A clinicopathologic review of keratocystic odontogenic tumours seen at the Lagos University Teaching Hospital
Objectives: The aim of the study was to review all cases of keratocystic odontogenic tumours (KCOTs) seen over a 37-year (1972-2008) at Department of Oral Pathology & Oral Biology and Oral & Maxillofacial Surgery of the Lagos University Teaching Hospital with a view to highlighting the age, sex, location of lesion, radiological and histological features of the lesion. Methods: Clinical and histological information on all cases of histologically diagnosed KCOTs seen during the period were retrieved and analyzed based on the following: age, sex, site of lesion, radiographic presentation, duration as at time of hospital presentation, radiographic features and histological features. Result: Fifty-four cases of KCOTs were recorded of which 39 (72.2%) were in males and 15 (27.8%) in females. The peak incidence of occurrence was in the 4th decade of life (31.5%). Forty-six (85.2%) tumours were located in the mandible and only eight (14.8%) were located in the maxilla with the mandible -maxilla ratio of 5.8:1. The most common site of involvement was the 1st and 2nd molar region (42.6%) of both jaws. Multilocular radiolucency was the most common radiographic appearance while parakeratinised form of epithelial lining was the most common histologic form. Ameloblastoma (19 cases), followed by dentigerous cyst (13 cases) were the most common clinical diagnosis made for the KCOTs. There was no cyst associated with Gorin-Gortz syndrome (GGS). Conclusion: KCOTs commonly occur in the 4th decade of life and in the mandible. The most common jaw location of KCOTs is the 1st and 2nd molar region with male preponderance. No case of GGS was recorded in our study; therefore, the association of KCOTs with GGS is an infrequent finding in this environment.