Comparative Invitro Studies of Erythromycin Stearate Tablets Commercially Available in Lagos State, Nigeria
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Date
2016-01
Authors
Ogah, C.O.
Journal Title
Journal ISSN
Volume Title
Publisher
SRYAHWA, USA
Abstract
Erythromycin is a macrolide antibiotic with a broad spectrum of activity against gram-positive and some gram-negative bacteria. It is unstable at acid pH, this makes its form of presentation have great effect on its activity. In this study, we evaluated the physicochemical properties of the drug using methods described in the BP, content of the active ingredient was evaluated by means of UV/VIS spectrophotometer at 480nm wavelength and dissolution study was done using the USP method. Results showed that 70% of the samples passed the test for content of active ingredient, 100% passed the friability test, 30% failed the weight uniformity test while 90% were harder than the innovator brand. There was a statistically significant difference between disintegration time in acid and buffer solution. Dissolution tests showed that 30% failed to meet the USP standard for erythromycin. The study revealed that 30% of the brands studied were of poor quality.
Description
Scholarly articles
Keywords
Erythromycin , Dissolution , Equivalence , Bacteria , Macrolide antibiotic , Research Subject Categories::PHARMACY
Citation
Ogah, C.O. (2016). Comparative Invitro Studies of Erythromycin Stearate Tablets Commercially Available in Lagos State, Nigeria. International Journal of Research in Pharmacy and Biosciences; 3(1): 7-13.