COMPARATIVE ALKYLATING ACTIVITY OF AQUEOUS ROOT BARK EXTRACT OF SECURIDACA LONGEPEDUNCULATA (POLYGALACEAE) AND CHLORAMBUCIL USING THE NITROBENZYL PYRIDINE ASSAY
No Thumbnail Available
Date
2018
Authors
Ebuehi, O.A.T.
LAWAL, R.A
ODESANMI O.S
NKEMEHULE, F
LAWAL, S.K
ATANDA, J.F
JIMOH, Y.O
Journal Title
Journal ISSN
Volume Title
Publisher
Journal Industrial Research and Technology
Abstract
Securidacalongepedunculata (polygalaceae) is a shrub found growing in Nigeria and some parts of Africa. Several studies support its reported cytotoxicity to cancer cells. However, the mechanism by which it cures cancer has not been fully elucidated. The aim of the study is to compare the alkylating activity of aqueous root-bark extract of S. longepedunculata (polygalaceae) and chlorambucil. The nitrobenzyl pyridine assay was used to determine the alkylating activity of S. longepunculata. The results indicate a time- and concentration-dependent increase in alkylating activity of S.
longepedunculata. Securidacalongepedunculata shows cytotoxicity through its alkylating activity which is comparable to chlorambucil.
Description
Scholarly article
Keywords
Citation
LAWAL, R.A, IODESANMI O.S, NKEMEHULE, F. (2018). COMPARATIVE ALKYLATING ACTIVITY OF AQUEOUS ROOT BARK EXTRACT OF SECURIDACA LONGEPEDUNCULATA (POLYGALACEAE) AND CHLORAMBUCIL USING THE NITROBENZYL PYRIDINE ASSAY. Journal Industrial Research and Technology 7(1):53-57