Browsing by Author "Abate, F."

Now showing items 1-9 of 9

  • Association Studies and Direct DNA Sequencing Implicate Genetic Susceptibility Loci in the Etiology of Nonsyndromic Orofacial Clefts in Sub-Saharan African Populations. 

    Gowans, L.J.J.; Adeyemo, W.L.; Eshete, M.; Mossey, P.A.; Busch, T.; Aregbesola, B.; Donkor, P.; Arthur, F.K.; Bello, S.A.; Martinez, A.; Li, M.; Augustine-Akpan, E.A.; Deressa, W.; Twumasi, P.; James, O.; Deribew, M.; Agbenorku, P.; Oti, A.A.; Braimah, R.; Plange-Rhule, G.; Gesses, M.; Obiri-Yeboah, S.; Oseni, G.O.; Olaitan, P.B.; Abdur-Rahman, L.A.; Abate, F.; Hailu, T.; Gravem, P.; Ogunlewe, M.O.; Buxo, C.J.; Marazita, M.L.; Adeyemo, A.A.; Murray, J.C.; Butali, A. (SAGE JOURNALS, 2016-10-01)
    Orofacial clefts (OFCs) are congenital dysmorphologies of the human face and oral cavity, with a global incidence of 1 per 700 live births. These anomalies exhibit a multifactorial pattern of inheritance, with genetic and ...
  • Genomic analyses in African populations identify loci for cleft palate 

    Butali, A.; Mossey, P.A.; Adeyemo, W.L.; Eshete, M.A.; Gowans, L.J.J.; Busch, T.; Jain, D.; Yu, W.; Huan, L.; Laurie, C.C.; Laurie, C.A.; Nelson, S.; Li, M.; Sanchez-Lara, P.A.; Magee, W.P.; Magee, K.S.; Auslander, A.; Brindopke, F.; Kay, D.M.; Caggana, M.; Romitti, P.A.; Mills, J.L.; Audu, R.; Onwuamah, C.; Oseni, G.O.; Owais, A.; James, O.; Olaitan, P.B.; Aregbesola, B.S.; Braimah, R.O.; Oginni, F.O.; Oladele, A.O.; Bello, S.A.; Rhodes, J.; Shiang, R.; Donkor, P.; Obiri-Yeboah, S.; Arthur, F.K.N.; Twumasi, P.; Agbenorku, P.; Plange-Rhule, G.; Oti, A.; Ogunlewe, M.O.; Oladega, A.A.; Adekunle, A.A.; Erinoso, A.O.; Adamson, O.O.; Elufowoju, A.A.; Ayelomi, O.I.; Hailu, T.; Hailu, A.; Demissie, Y.; Derebew, M.; Eliason, S.; Romero-Bustillous, M.; Lo, C.; Park, J.; Desai, S.; Mohammed, M.; Abate, F.; Abdur-Rahman, L.O.; Anand, D.; Saadi, I.; Oladugba, A.V.; Lachke, S.A.; Amendt, B.A.; Rotimi, C.N.; Marazita, M.L.; Cornell, R.A.; Murray, J.C.; Adeyemo, A.A. (Oxford Academic, 2019-03-15)
    Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or ...
  • Identification of paternal uniparental disomy on chromosome 22 and a de novo deletion on chromosome 18 in individuals with orofacial clefts 

    Oseni, G.O.; Jain, D.; Mossey, P.A.; Busch, T.D.; Gowans, L.J.J.; Eshete, M.A.; Adeyemo, W.L.; Laurie, C.A.; Laurie, C.C.; Owais, A.; Olaitan, P.B.; Aregbesola, B.S.; Oginni, F.O.; Bello, S.A.; Donkor, P.; Audu, R.; Onwuamah, C.; Obiri-Yeboah, S.; Plange-Rhule, G.; Ogunlewe, M.O.; James, O.; Hailu, T.; Abate, F.; Abdur-Rahman, L.O.; Oladugba, A.V.; Marazita, M.L.; Murray, J.C.; Adeyemo, A.A.; Butali, A. (Wiley, 2018-11-01)
    BACKGROUND: Orofacial clefts are the most common malformations of the head and neck region. Genetic and environmental factors have been implicated in the etiology of these traits. METHODS: We recently conducted genotyping ...
  • Loss-of-Function GRHL3 Variants Detected in African Patients with Isolated Cleft Palate 

    Eshete, M.A.; Liu, H.; Li, M.; Adeyemo, W.L.; Gowans, L.J.J.; Mossey, P.A.; Busch, T.; Deressa, W.; Donkor, P.; Donkor, P.; Olaitan, P.B.; Aregbesola, B.S.; Braimah, R.O.; Oseni, G.O.; Oginni, F.; Audu, R.; Onwuamah, C.; James, O.; Augustine-Akpan, E.; Rahman, L.A.; Ogunlewe, M.O.; Arthur, F.K.N.; Bello, S.A.; Agbenorku, P.; Twumasi, P.; Abate, F.; Hailu, A.; Demissie, Y.; Hailu, A.; Plange-Rhule, G.; Obiri-Yeboah, S.; Dunnwald, M.M.; Gravem, P.E.; Marazita, M.L.; Adeyemo, A.A.; Murray, J.C.; Cornell, R.A.; Butali, A. (SAGE JOURNALS, 2018-01-01)
    In contrast to the progress that has been made toward understanding the genetic etiology of cleft lip with or without cleft palate, relatively little is known about the genetic etiology for cleft palate only (CPO). A common ...
  • A multi-ethnic genome-wide association study identifies novel loci for nonsyndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q31. 

    Leslie, E.J.; Carlson, J.C.; Shaffer, J.R.; Feingold, E.; Wehby, G.; Laurie, C.A.; Jain, D.; Laurie, C.C.; Doheny, K.F.; McHenry, T.; Resick, J.; Sanchez, C.; Jacobs, J.; Emanuele, B.; Vieira, A.R.; Neiswanger, K.; Lidral, A.C.; Valencia-Ramirez, L.C.; Lopez-Palacio, A.M.; Valencia, D.R.; Arcos-Burgos, M.; Czeizel, A.E.; Field, L.L.; Padilla, C.D.; Cutiongco-de la Paz, E.M.; Deleyiannis, F.; Christensen, K.; Munger, R.G.; Lie, R.T.; Wilcox, A.; Romitti, P.A.; Castilla, E.E.; Mereb, J.C.; Poletta, F.A.; Orioli, I.M.; Carvalho, F.M.; Hecht, J.T.; Blanton, S.H.; Buxo, C.J,; Butali, A.; Mossey, P.A.; James, O.; Braimah, R.O.; Aregbesola, B.S.; Eshete, M.A.; Abate, F.; Koruyucu, M.; Seymen, F.; Ma, L.; Enríquez de Salamanca, J.; Weinberg, S.; Moreno, L.; Murray, J.C.; Marazita, M.L. (Oxford Academic, 2016-07-01)
    Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate (CL/P), are among the most common birth defects in humans, affecting approximately 1 in 700 newborns. CL/P is phenotypically ...
  • Non‐random distribution of deleterious mutations in the DNA and protein‐binding domains of IRF6 are associated with Van Der Woude syndrome 

    Alade, A.A.; Buxo‐Martinez, C.J.; Mossey, P.A.; Gowans, L.J.J.; Eshete, M.A.; Adeyemo, W.L.; Naiker, T.; Awotoye, W.A.; Adeleke, C.; Busch, T.; Torano, A.M.; Bello, C.A.; Soto, M.; Ledesma, R.; Marquez, M.; Cordero, J.F.; Lopez‐Del Valle, L.M.; Salcedo, M.I.; Debs, N.; Li, M.; Petrin, A.; Olotu, J.; Aldous, C.; James, O.; Ogunlewe, M.O.; Abate, F.; Hailu, T.; Muhammed, I.; Gravem, P.; Deribew, M.; Gesses, M.; Hassan, M.; Pape, J.; Adeniyan, O.A.; Obiri‐Yeboah, S.; Arthur, F.K.N.; Oti, A.A.; Olatosi, O.; Miller, S.E.; Donkor, P.; Dunnwald, M.M.; Marazita, M.L.; Adeyemo, A.A.; Murray, J.C.; Butali, A. (Wiley, 2020-06-17)
    Background: The development of the face occurs during the early days of in-trauterine life by the formation of facial processes from the first Pharyngeal arch. Derangement in these well-organized fusion events results in ...
  • Novel IRF6 mutations in families with Van Der Woude syndrome and popliteal pterygium syndrome from sub-Saharan Africa. 

    Butali, A.; Mossey, P.A.; Adeyemo, W.L.; Eshete, M.A.; Gaines, L.A.; Even, D.; Braimah, R.O.; Aregbesola, B.S.; Rigdon, J.V.; Emeka, C.I.; James, O.; Ogunlewe, M.O.; Ladeinde, A.L.; Abate, F.; Hailu, T.; Mohammed, I.; Gravem, P.E.; Deribew, M.; Gesses, M.; Adeyemo, A.A.; Murray, J.C. (Wiley, 2014-05-01)
    Orofacial clefts (OFC) are complex genetic traits that are often classified as syndromic or nonsyndromic clefts. Currently, there are over 500 types of syndromic clefts in the Online Mendelian Inheritance in Man (OMIM) ...
  • The prevalence, penetrance, and expressivity of etiologic IRF6 variants in orofacial clefts patients from sub-Saharan Africa 

    Gowans, L.J.J.; Busch, T.D.; Mossey, P.A.; Eshete, M.A.; Adeyemo, W.L.; Aregbesola, B.; Donkor, P.; Arthur, F.K.; Agbenorku, P.; James, O.; Twumasi, P.; Braimah, R.; Oti, A.A.; Plange-Rhule, G.; Obiri-Yeboah, S.; Abate, F.; Hoyte-Williams, P.E.; Hailu, T.; Murray, J.C.; Butali, A. (Wiley, 2017-01-01)
    BACKGROUND: Orofacial clefts are congenital malformations of the orofacial region, with a global incidence of one per 700 live births. Interferon Regulatory Factor 6 (IRF6) (OMIM:607199) gene has been associated with the ...
  • Rare functional variants in genome-wide association identified candidate genes for nonsyndromic clefts in the African population. 

    Butali, A.; Mossey, P.A.; Adeyemo, W.L.; Eshete, M.; Gaines, L.; Braimah, R.; Aregbesola, B.; Rigdon, J.; Emeka, C.; James, O.; Ogunlewe, M.O.; Ladeinde, A.L.; Abate, F.; Hailu, T.; Mohammed, I.; Gravem, P.; Deribew, M.; Gesses, M.; Adeyemo, A.; Marazita, M.L.; Murray, J.C. (Wiley, 2014-10-01)
    Nonsyndromic clefts of the lip and palate (NSCLP) are complex genetic traits. Together, they are classified as one of the most common birth defects with a prevalence of 1/700 live births. Genome-wide association studies ...