Medicine- Conference papers

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Browsing Medicine- Conference papers by Author "Adeyemi-Doro, A"

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    Open Access
    Comparison of the glycaemic responses of Fumman® orange juice with other juice products in Nigerian type 2 diabetes mellitus patients.
    (Nigerian Society of Endocrinology and Metabolism, 2007-09) Ohwovoriole, A.E; Fasanmade, O.A; Coker, A.O; Odeniyi, I.A; Adeyemi-Doro, A; Iwuala, S.O
    Objective To compare the glycaemic responses and load of Fumman® orange juice with other juice products in persons with type 2 diabetes mellitus in Nigeria. Methods A cross-sectional case-controlled study was carried out. Ten subjects with well-controlled type 2 diabetes mellitus (HbA1c< 7%) on oral agents, with age and sex-matched controls, were recruited for the study. Subjects and controls had a food tolerance test with Fumman’® juice, fresh orange juice, and another commercial juice. Glycaemic responses were assessed in all study subjects using incremental glucose, incremental area under the glucose curve, and peak plasma glucose. Results Fumman® juice had a significantly lower Incremental Glucose in Diabetes subjects than Commercial Juice (p = 0.026), had the lowest mean incremental area under the glucose curve which was significantly lower than commercial juice (p=0.02), but not significantly lower than natural juice. Fumman® also had the lowest peak plasma glucose levels, which were significantly lower than commercial juice (p=0.025). Conclusion The glycaemic responses of Fumman® orange juice as observed in diabetes subjects are significantly lower than that of the commercial juice
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    Open Access
    Gigantism associated with hypopituitarism: a case report
    (Nigerian Society of Endocrinology and Metabolism, 2007-09) Odeniyi, I.A; Adeyemi-Doro, A; Ekpebegh, C.O; Fasanmade, O.A; Awosanya, G.O; Ohwovoriole, A.E
    Background Gigantism is a rare disorder, a major cause of which is hyperpituitarism. Even rarer is hyperpituitarism causing gigantism in the company of pituitary failure. Objective To present an unusual case of gigantism due to pituitary tumour in a patient who was also having features of hypopituitarism. Case report An 18-year-old male Nigerian diagnosed as having gigantism secondary to a pituitary adenoma is reported in this communication. He was referred from the orthopaedic clinic where he was being managed for a fracture. He was very tall compared with his siblings and peers. Pregnancy and early childhood were uneventful. He had excessive somnolence, sluggishness and weight gain. He weighed 114 kg with a height of 2.10m. His upper segment was 1.0m with a lower segment of 1.10m. The arm span was 2.32m. He had thick lips with large hands and feet. There was bilateral gynaecomastia with milky nipple discharge. He had scanty axillary hair but his pubic hair distribution was Tanner stage 4. He had bitemporal hemianopia, diminished reflexes globally, but no delayed relaxation phase of the ankle reflex. His pulse rate was 86bpm; his blood pressure was 90/60mmbg. Basal growth hormone was markedly elevated. Basal Prolactin was also elevated. Thyroid and testicular functions were impaired. Basal cortisol and stimulated cortisol were equivocal. OGTT with serial growth hormone measurement showed no suppression of growth hormone. imaging studies confirmed enlarged pituitary fossa due to pituitary tumour. The problems with this patient were hyperpituitarism with hyperprolactinaemia, hypothyroidism, hypogonadism and borderline adrenocortical function. He was commenced on bromocriptine and hormonal replacement. Conclusion This case highlights delayed diagnosis and the concomitant presence of hyperpituitarism and hypopituitarism. In the short term, patients can be controlled medically but long-term management poses challenges.
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    Open Access
    Precocious puberty and HIV infection: A possible emerging Endocrinopathy?
    (American Association of Clinical Endocrinologists, 2008) Iwuala, S.O; Adeyemi-Doro, A; Sabir, A; Odeniyi, I.A; Fasanmade, O.A
    Background: HIV infection and/or its treatment are associated with a variety ofendocrinopathies. However, precocious puberty ascribable to HIV infection appears to be very rare. Objective: To report a case of precocious puberty associated with HIV infection and review the association between HIV and precocious puberty. Methods: A boy with evidence of premature puberty was referred for endocrine evaluation and management. A full history and physical examination were performed. Investigations carried out included bone age determination, abdominal ultrasound, cranial X-rays, and basal gonadal evaluation. He was subsequently managed with progestogens to arrest further sexual development. The boy presented at age six years with an 11-month history of the appearance of features of puberty but denied a history of ejaculations or sexual relationship. He had tested positive for HIV five months prior to presentation after his mother was found to be seropositive. The patient denied a history of blood transfusion. Pregnancy and early childhood were unremarkable. Physical examination revealed a healthy-looking big for age boy, without café-au-lait spots, visual field defects, or palpable organ enlargement intra-abdominally. He was 1.48 m tall and weighed 39 kg. The B.P. was 80/60 mmHg. He had pubic hair of Tanner stage 4. The testes and phallus were of adult size. Lab results: Basal plasma hormone assays showed testosterone of0.8ng/ml(normal), , LH of 13mlU/ml (normal for puberty), FSH of 10mlU/ml (normal for puberty), 9.00am serum Cortisol 170ng/ml(normal), DHEAS of 550ng/ml (high). His bone age was between 9 to 14 years. Abdominal USS and skull X-rays were normal. He could not afford further investigations. He was placed on medroxyprogesterone acetate. Pubertal development has since not Progressed. Conclusion: It is conjectural that HIV could have induced precocious puberty in this boy, but such association appears very rare as only one case could be found in the world literature. There is a need to establish whether this is one of the HIV-related endocrinopathies.