Department of Radiation Biology, Radiotherapy & Radiodiagnosis

Permanent URI for this community

https://ir.unilag.edu.ng/handle/123456789/3614

Browse

Browsing Department of Radiation Biology, Radiotherapy & Radiodiagnosis by Author "Adeneye, SO"

Now showing 1 - 2 of 2
  • Item
    Open Access
    Evaluation of temperature distributions during microwave ablation of ex vivo bovine liver using two types of antennas.
    (2019-03) Ibitoye, AZ; Nwoye, EO; Saseyi, AO; Adeneye, SO; Adedokun, MB; Aweda, MA
    Introduction: Temperature distributions during microwave ablation are dependent on the antenna types, antenna geometry, tissue properties, input power and ablation. All these factors can significantly affect the coagulation region, ablation length, ablation diameter, aspect ratio, backward heating (comic effect), and degree of necrosis. Temperature distributions during microwave ablation procedures determine the effectiveness of ablating tumours in tissue. Objective: The aim of this study is to evaluate temperature distributions during microwave ablation using sleeved and dual slot antennas. Materials and Methods: In this study, sleeved and dual slot antennas were designed using COMSOL MULTIPHYSICS software version 4.4. Temperature distributions were analyzed at 10 mm and 20 mm from the antennas’ surfaces. Dualslot and sleeved antennas were fabricated from 0.085’ 50 Ω semi-rigid coaxial cable to conform to numerical simulation. The antennas were applied on ex vivo bovine liver. Thermometer probes were placed at 10 mm and 20 mm from the antennas’ surfaces with the input powers set at 30, 50 and 80 W for 300 s. Before each ablation, the initial temperature was recorded whereas subsequent measurements were recorded at 50 s intervals. Numerical simulation and experimental obtained data were analyzed and compared using the student's t-test statistical tool. Results: The findings in this study showed that temperatures produced at the two points of measurements by the sleeved antenna were greater than that of the dual-slot antenna in simulation and experimental procedures. Also, there was no significant difference between simulation and experimentally results for dual-slot antenna and sleeved antenna (p = 0.25). Conclusion: In conclusion, the sleeved antenna has the potential to ablate a tumour faster above the tumoricidal temperatures at the same position than the dual-slot antenna.
  • Item
    Open Access
    Synthesis and Characterization of Iron Oxide Nanoparticles from Wonderful Kola seed for Future Application in Microwave Tumour Ablation
    (Academic Journals, 2021-08) Morakinyo, AD; Ibeh, JG; Aweda, MA; Adeyemi, DK; Oyenenin, AO; Ige, O; Ibitoye, AZ; Adeneye, SO
    The green method of synthesizing nanoparticles is an eco-friendly, reliable and cost effective approach which has proven to be an alternative to chemical based methods over the years (Dipankar and Murugan, 2012). This research focuses on the synthesis and characterization of super-paramagnetic iron oxide nanoparticles (FeNPs), adopted a co-precipitation procedure by the interaction of ferric chloride solution (precursor) with aqueous extract of wonderful kola seed. The characterization phase was investigated using the Ultra-violet visible spectroscopy, Fourier Transform Infra- red, X-ray Diffraction and Scanning Electron Microscopy. The SEM analysis showed that the particles have irregular shapes with the average particle diameter measured between 10 to 40 nm. The crystalline nature of the nanoparticles was confirmed by the X-ray diffraction method with the crystallite size range between 10 and 47 nm. The absorbance peak of the synthesized wonderful kola FeNPs was investigated using the ultra-violet visible spectroscopy with wavelengths of 431, 488, 613 and 642 nm and corresponding band gap energies of 2.87, 2.54, 2.02 and 1.93eV respectively; while the absorbance peak of wonderful kola extract has a wavelength of 256 nm with band gap energy of 4.84 eV showing the tendency of a new compound formed. The FTIR peak at 3336.0cm-1 corresponds to the –OH bond stretching, with a strong and broad peak intensity (S, B) indicating the presence of alcohols and phenol. The peak value at 1636.3 cm-1 corresponds to C=O bond stretching vibration with strong intensity, indicating the presence of carbonyl and acids. The peak values also denote the change in fundamental vibrational levels of most molecules present in the sample. The synthesized magnetic nanoparticles could be applied as an enhancement tool in microwave tumour ablation.