Off-Label Prescription for Paediatric In- And Out_Patients at a Tertiary Hospital in Lagos, Nigeria

Simple item page
dc.contributor.authorOreagba, I.A.
dc.contributor.authorOmotoso, K.S.
dc.contributor.authorJoda, A.E.
dc.contributor.authorSonibare, T
dc.contributor.authorOshikoya, K.A.
dc.date.accessioned2019-12-09T14:02:06Z
dc.date.available2019-12-09T14:02:06Z
dc.date.issued2015
dc.descriptionStaff publicationsen_US
dc.description.abstractThe licensing process of medicines aims at ensuring their safety, efficacy and quality. Although many medicines are not licenced for paediatric use, they are nevertheless prescribed for children outside the terms of their product license (off-label). Our main objective was to assess off-label prescribing and to document the level of this practice in paediatric patients attending a tertiary hospital in Lagos, Nigeria. Prescriptions received by children aged 16 years or less during a 24-month period (January 2010 to December 2011) were obtained from the case notes of randomly selected patients from a list of patients who had previously attended the Lagos University Teaching Hospital (LUTH). Data collected include demographic information, medicines prescribed and the nature of off-label medicine. A total of 1207 prescriptions were analysed from the case notes of 430 patients. Prevalence of Off-label prescription was 6.6% and commoner in males (62.5%) than females (37.5%). Young children, aged 1-5 years, (40.0%) and Infants, aged 1-12 months, (36.3%) were the two groups most commonly prescribed off-label medicines. Off-label prescription due to inappropriate dosage (38.7%) and unapproved age use (25%) were the two commonest categories observed in this study. Anti-infective (46.3%) and cardiovascular (38.7%) medicines were the two classes of off-label medicines most frequently prescribed. Off-label prescribing in paediatric patients is still prevalent however the magnitude is considerably lower than previously reported. Off-label prescribing should be evidence based and further studies should address the need for adequate dosing guidelines for such prescribed medicines.en_US
dc.identifier.citationOreagba, I.A., Omotoso, K.S, Joda, A.E., Sonibare, T. and Oshikoya, K.A. (2015). Off-Label Prescription for Paediatric In- And Out_Patients at a Tertiary Hospital in Lagos, Nigeria. West Afr. J. Pharmacol. Drug Res., 30:18-27en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7050
dc.language.isoenen_US
dc.publisherWest African Journal of Pharmacology and Drug Researchen_US
dc.relation.ispartofseriesWest Afr. J. Pharmacol. Drug Res.;Vol.30
dc.subjectOff-labelen_US
dc.subjectUnlicenseden_US
dc.subjectMedicineen_US
dc.subjectChildrenen_US
dc.subjectPaediatricsen_US
dc.subjectHospitalen_US
dc.subjectPrescriptionen_US
dc.subjectLagos Stateen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleOff-Label Prescription for Paediatric In- And Out_Patients at a Tertiary Hospital in Lagos, Nigeriaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2015 WAJPDR Off-Label use of drugs in paediatric patients.pdf
Size:
123.29 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Clinical Pharmacy and Biopharmacy- Scholarly Publications