Prevalence of ethanol and other potentially harmful excipients in pediatric oral medicines: survey of community pharmacies in a Nigerian City

dc.contributor.authorSoremekun, R.O
dc.contributor.authorOgbuefi, I
dc.contributor.authorAderemi-Williams, R.I.
dc.date.accessioned2021-06-04T10:54:49Z
dc.date.available2021-06-04T10:54:49Z
dc.date.issued2019
dc.descriptionScholarly articleen_US
dc.description.abstractObjective: Excipients are needed in the formulation of oral liquid medicines intended for children; they have how‑ever been reported to trigger safety issues. This study evaluated the concentrations and prevalence of ethanol and other potentially harmful excipients in pediatric formulations marketed in South Eastern Nigeria in line with international labeling guidelines and allowable daily limits (ADL). The study sampled oral pediatric formulations offered for sale in registered pharmacies. Those with accessible information leaflets were assessed for the presence and quantity of previously fagged excipients with potential to harm the pediatric population. Result: Of the 380 oral pediatric medicines, 140 provided access to list/quantity of ingredients. 47.9% (67) of the formulations contain at least one of the fagged excipients while the remaining only listed the active ingredients. Ethanol had the highest occurrence (62.7%) and was more in cough/cold medicines. A homeopathic cough and cold remedy had concentration of 90% v/v. Ethanol and sucrose in some formulations exhibited concentrations with a potential of crossing their approved daily intake (ADI) (1–90% v/v and 1.7 g–3.7 g/5 ml respectively). Ethanol use in studied pediatric formulations was quite high, with ethanol-containing formulations being prescribed for children 0–6 years and older. Only 26 (38.8%) completely satisfied the labelling requirements for ethanol containing formulationsen_US
dc.identifier.citationSoremekun R, Ogbuefi I and Aderemi-Williams R (2019) Prevalence of ethanol and other potentially harmful excipients in paediatric oral medicines: survey of community pharmacies in a Nigerian City. BMC Research Notes, 12:460.en_US
dc.identifier.urihttps://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4486-7.
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9441
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofseriesBMC Research Notes;12
dc.subjectPediatricsen_US
dc.subjectOral liquid medicinesen_US
dc.subjectEthanolen_US
dc.subjectExcipientsen_US
dc.subjectCommunity pharmacyen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titlePrevalence of ethanol and other potentially harmful excipients in pediatric oral medicines: survey of community pharmacies in a Nigerian Cityen_US
dc.typeArticleen_US
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