Replication of GWAS significant loci in a Sub-Saharan African Cohort with Early Childhood Caries: a pilot study

Simple item page
dc.contributor.authorOlatosi, O.O.
dc.contributor.authorLi, M.
dc.contributor.authorAlade, A.A.
dc.contributor.authorOyapero, A.
dc.contributor.authorBusch, T.
dc.contributor.authorPape, J.
dc.contributor.authorOlotu, J.
dc.contributor.authorAwotoye, W.
dc.contributor.authorHassan, M.
dc.contributor.authorAdeleke, C.
dc.contributor.authorAdeyemo, W.L.
dc.contributor.authorSote, E.O.
dc.contributor.authorShaffer, J.R.
dc.contributor.authorMarazita, M.L.
dc.contributor.authorButali, A.
dc.date.accessioned2021-05-24T07:11:00Z
dc.date.available2021-05-24T07:11:00Z
dc.date.issued2021-05-22
dc.description.abstractBackground: Early childhood caries (ECC) is a rapidly progressing form of dental infection and a significant public health problem, especially among socially and economically disadvantaged populations. This study aimed to assess the risk factors for ECC among a cohort of Sub-Saharan African children and to determine the role of genetics in the etiology of ECC. Methods: A sample of 691 children (338 with ECC, 353 without ECC, age < 6 years) was recruited from schools in Lagos, Nigeria. Socio-demographic, dental services utilization and infant dietary data were obtained with interviewer-administered questionnaire. Oral examination was conducted using the WHO oral health diagnostic criteria. Saliva samples were collected from the children for genetic analysis. Single nucleotide polymorphisms were selected from previous study for genotyping. Genetic association analyses to investigate the role of genetics in the etiology of ECC was done. Bivariate comparisons and Multivariate logistic regression analyses were conducted to assess associations between ECC and predictor variables, p < 0.05. Results: Of the 338 children with ECC, 64 (18.9%) had Severe-Early Childhood Caries (S-ECC). Children aged 48-59 months comprised the highest proportion of subjects with ECC (165; 48.8%) and S-ECC (24; 37.5%) while female subjects had higher dt (3.13 ± 2.56) and dmft values 3.27 ± 2.64. ECC was significantly more prevalent among children who were breastfed at night ≥ 12 months (OR 3.30; CI 0.39, 4.75), those with no previous dental visit (OR 1.71; CI 0.24, 2.77), those who used sweetened pacifiers (OR 1.85; CI 0.91, 3.79) and those who daily consumed sugar-sweetened drinks/snacks (OR 1.35; CI 0.09, 18.51). A suggestive increased risk for ECC (OR 1.26, p = 0. 0.0397) was observed for the genetic variant rs11239282 on chromosome 10. We also observed a suggestive reduced risk for ECC (OR 0.80, p = 0.03) for the rs131777 on chromosome 22. None of the genetic variants were significant after correction for multiple testing (Bonferroni p value p = 0.004). Conclusions: Prolonged night-time breastfeeding, poor utilization of dental services and daily consumption of sugar were risk factors for ECC. Larger sample size is needed to confirm the results of the genetic analysis and to conduct genome wide studies in order to discover new risk loci for ECC. Keywords: Early childhood caries (ECC); Genetics; Prevalence; Risk factors; Severe early childhood caries.en_US
dc.description.sponsorshipScholarly articlesen_US
dc.identifier.citationOlatosi OO, Li M, Alade AA, Oyapero A, Busch T, Pape J, Olotu J, Awotoye W, Hassan M, Adeleke C, Adeyemo WL, Sote EO, Shaffer JR, Marazita ML, Butali. Replication of GWAS significant loci in a Sub-Saharan African Cohort with Early Childhood Caries: a pilot study. BMC Oral Health 2021;21(1):274. doi: 10.1186/s12903-021-01623-yen_US
dc.identifier.otherdoi: 10.1186/s12903-021-01623-y
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9429
dc.language.isoenen_US
dc.publisherBMCen_US
dc.subjectEarly Childhood Cariesen_US
dc.subjectGeneticsen_US
dc.subjectPrevalenceen_US
dc.subjectRisk factorsen_US
dc.subjectResearch Subject Categories::ODONTOLOGYen_US
dc.titleReplication of GWAS significant loci in a Sub-Saharan African Cohort with Early Childhood Caries: a pilot studyen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Olatosi et al. BMC Oral Health 2021.pdf
Size:
882.83 KB
Format:
Adobe Portable Document Format
Description:
Research Article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Oral and Maxillofacial Surgery - Scholarly Publications