Short‑term Effect of Tamsulosin and Finasteride Monotherapy and their Combination on Nigerian Men with Benign Prostatic Hyperplasia

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dc.contributor.authorOdusanya, B.O.
dc.contributor.authorTijani, K.H.
dc.contributor.authorJeje, E.A.
dc.contributor.authorOgunjimi, M.A.
dc.contributor.authorOjewola, R.W.
dc.date.accessioned2020-02-21T12:54:54Z
dc.date.available2020-02-21T12:54:54Z
dc.date.issued2017-01
dc.descriptionStaff publicationsen_US
dc.description.abstractObjective: The objective of this study was to assess the efficacy of tamsulosin and finasteride monotherapies, and their combination in men with benign prostatic hyperplasia (BPH). Materials and Methods: This is a prospective single‑blind randomized study of ninety men with BPH who were managed using drugs. The International Prostate Symptom Score (IPSS), peak urinary flow rate, and prostate volume were measured as parameters for assessment at the beginning, 3 months, and 6 months of the study. Results: The mean age of patients was 61.65 with a range of 44–81 years. There was a progressive and sustained improvement in the IPSS score in all patient groups with mean decrease at 3 months of 7.24 (42.59%), 7.60 (41.85%), and 7.24 (40.61%) and at 6 months of 8.14 (47.88%), 10.33 (56.88%), and 11.1 (62.25%) in the tamsulosin, finasteride, and combination groups, respectively. There was an increase in peak urinary flow rate in all groups with mean increase at 3 months of 0.98, 0.05, and 3.55 (ml/s) and at 6 months of 4.11, 0.87, and 3.74 (ml/s) in the tamsulosin, finasteride, and combination groups, respectively. There was a reduction in the prostate volume in the finasteride and combination groups at 6 months of 6.8 and 6.32 cm3, respectively, while the tamsulosin group recorded an increase. Conclusion: At the end of 6 months, tamsulosin monotherapy and combination therapy appear to be equally effective in the treatment of lower urinary tract symptoms BPH while finasteride monotherapy appears to be the least effective. Bothersome, side effects were more in patients taking finasteride alone or as combination therapy.en_US
dc.identifier.citationOdusanya BO, Tijani KH, Jeje EA, Ogunjimi MA, Ojewola RW. Short-term effect of tamsulosin and finasteride monotherapy and their combination on nigerian men with benign prostatic hyperplasia. Niger J Surg 2017;23:5-10.en_US
dc.identifier.otherDOI: 10.4103/1117-6806.199963
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7777
dc.language.isoenen_US
dc.publisherWolters Cluwer - Nigerian Surgical Research Society & Association of Surgeons of Nigeriaen_US
dc.relation.ispartofseriesNiger J Surg;Vol.23
dc.subjectBenign prostatic hyperplasiaen_US
dc.subjectCombinationen_US
dc.subjectFinasterideen_US
dc.subjectTamsulosinen_US
dc.subjectResearch Subject Categories::MEDICINE::Surgeryen_US
dc.titleShort‑term Effect of Tamsulosin and Finasteride Monotherapy and their Combination on Nigerian Men with Benign Prostatic Hyperplasiaen_US
dc.typeArticleen_US
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