Adrenocortical function in Nigerians with human immunodeficiency virus infection
| dc.contributor.author | Odeniyi, I. | |
| dc.contributor.author | Fasanmade, O. | |
| dc.contributor.author | Ajala, M.O. | |
| dc.contributor.author | Ohwovoriole, A. | |
| dc.date.accessioned | 2019-11-12T11:54:20Z | |
| dc.date.available | 2019-11-12T11:54:20Z | |
| dc.date.issued | 2013-12 | |
| dc.description | Staff publications | en_US |
| dc.description.abstract | OBJECTIVE: This study sets out to determine the prevalence of adrenocortical insufficiency in persons with HIV infection by determining the response to low-dose (1 µg) ACTH stimulation. DESIGN: An experimental study involving people with HIV infection and healthy people. SETTING: The study group and the controls were recruited from the Lagos University Teaching Hospital (LUTH). PARTICIPANTS: forty-three newly diagnosed and treatment naïve persons with HIV (23 males and 20 females) and 70 (35 males and 35 females) HIV negative subjects completed the study. INTERVENTION: One µg Synacthen was given intravenously to stimulate the adrenal glands. MAIN OUTCOME MEASURES: Blood was collected for basal cortisol levels and 30 minutes after the injection of ACTH. Cortisol was assayed using ELISA. RESULTS: The mean basal cortisol was 154.9 ± 27.2 nmol/L and 239.9 ± 31.6 nmol/L (p<0.001); while the 30-minute post ACTH test cortisol level was 354.8 ± 19.9 nmol/L and 870.9 ± 163.5 nmol/L (p<0.001) and the increment was 100.0 ± 17.2 nmol/L and 588.8 ± 143.4 nmol/L (p<0.001) in HIV and healthy subject group respectively. Using the diagnostic criteria derived for the diagnosis of adrenocortical insufficiency in this study (30 minute cortisol level <380.2 nmol/L and increment from basal to stimulated cortisol level <158.5 nmol/L); fifteen (34.8%) persons with HIV had adrenal insufficiency. CONCLUSION: Adrenocortical insufficiency is common in persons with HIV infection, occurring in about 34.8% of patients studied. Clinically evident adrenocortical insufficiency is uncommon in persons with HIV. | en_US |
| dc.identifier.citation | Odeniyi IA, Fasanmade OA, Ajala MO, Ohwovoriole AE. Adrenocortical function in Nigerians with human immunodeficiency virus infection. Ghana Med J. 2013 Dec;47(4):171-7. | en_US |
| dc.identifier.issn | 08550328 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/6824 | |
| dc.language.iso | en | en_US |
| dc.publisher | Ghana Medical Association | en_US |
| dc.relation.ispartofseries | Ghana Med J.;Vol.47(4) | |
| dc.subject | adrenocorticotropic hormone (ACTH) | en_US |
| dc.subject | Cortisol | en_US |
| dc.subject | Human immunodeficiency virus (HIV) | en_US |
| dc.subject | Research Subject Categories::MEDICINE | en_US |
| dc.title | Adrenocortical function in Nigerians with human immunodeficiency virus infection | en_US |
| dc.type | Article | en_US |