Preterm delivery and low maternal serum cholesterol level: Any correlation?

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Oluwole, AA
Adegbesan-Omilabu, M
Okunade, KS
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Background: The study assessed whether low maternal serum cholesterol during early pregnancy is associated with preterm delivery. Patients and Methods: It was a prospective observational cohort study involving pregnant women at gestational age of 14-20 weeks over a period of 12 months. Blood samples were obtained to measure total serum cholesterol concentrations and the sera were then analysed enzymatically by the cholesterol oxidase: p-aminophenazone (CHOD PAP) method. Results: The study showed an incidence of 5.0% for preterm delivery in the low risk study patients. Preterm birth was 4.83-times more common with low total maternal cholesterol than with midrange total cholesterol (11.8% versus 2.2%, P = 0.024). Conclusion: Low maternal serum cholesterol (hypocholesterolaemia) is associated with preterm delivery. Optimal maternal serum cholesterol during pregnancy may have merit, therefore pregnant women should be encouraged to follow a healthy, balanced diet.
Scholarly articles
Hypocholesterolaemia , Preterm birth , Preterm delivery , Perinatal mortality , Research Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseases::Obstetrics and gynaecology
Oluwole AA, Adegbesan-Omilabu M, Okunade KS. Preterm delivery and low maternal serum cholesterol level: Any correlation? Niger Med J 2014; 55(5): 406-10.