Comparative incidence of adverse drug reactions during the first and subsequent year of antiretroviral therapy in a Nigeria HIV infected cohort

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dc.contributor.authorAbah, I.O.
dc.contributor.authorDayom, W.D.
dc.contributor.authorDangiwa, D.A.
dc.contributor.authorAderemi-Williams, R.I.
dc.contributor.authorAguiyi, J.
dc.contributor.authorAnejo-Okopi, J.
dc.contributor.authorAgbaji, O.O.
dc.contributor.authorKanki, P.
dc.contributor.authorAguiyi, J.C.
dc.date.accessioned2022-01-12T07:45:34Z
dc.date.available2022-01-12T07:45:34Z
dc.date.issued2021
dc.descriptionScholarly articlesen_US
dc.description.abstractBackground: Despite close to two decades of antiretroviral therapy (ART) in Nigeria, data on late on-onset ART-associated adverse drug reactions (ADRs) are sparse. Objectives: To describe early and late-onset ADRs and compare their incidence in an outpatient HIV positive Cohort on ART. Method: We described the incidence of clinical ADRs identified and documented in an outpatient clinic cohort of HIV-positive patients treated between June 2004 and December 2015 at a tertiary health facility in Nigeria. Incidence rates of ADRs during the first and subsequent years of ART were compared. Results: of the 13,983 patients’ data analyzed, 9317 were females (66%), and those in the age bracket of 25 to 45 years made up 78% of the studied population. During 52,411 person-years (py) of ART, 1485 incident ADRs were recorded; Incidence rate (IR) 28.3 (95% confidence interval [CI] 26.9:29.8) ADRs per 1000 person-years (py) of ART. The IR of ADRs was about two times higher in the first year of ART compared to subsequent years of treatment; crude incidence rate ratio (IRR) 1.77 (95% CI 1.59:1.97). Anemia, hypersensitivity reactions, and nervous system disorders had 7, 23, and 5 times higher incidence, respectively, in the first year of therapy, compared to subsequent years. Conclusion: The first year of ART is the period of highest risk of ADRs. Individual and programmatic treatment success in resource-limited settings requires strategies for early identification and management of ADR during the period of greatest risk of ADRs.en_US
dc.description.sponsorshipThe Fogarty International Center and National Institute of Mental Health, of the National Institutes of Health under Award Number D43 TW010543, supported research reported in this publicationen_US
dc.identifier.citationAbah I. Dayom WD, Dangiwa DA, Aderemi-Williams R, Anejo-Okopi J, Agbaji OO, Kanki P & Aguiyi JC (2021) Comparative incidence of adverse drug reactions during the first and subsequent year of antiretroviral therapy in a Nigeria HIV infected cohort. African Health Sciences 21(3):1027 – 1039.en_US
dc.identifier.otherDOI: 10.4314/ahs.v21i3.10
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10152
dc.language.isoenen_US
dc.publisherAfrican Health Sciencesen_US
dc.subjectAdverse drug eventsen_US
dc.subjectantiretroviral therapyen_US
dc.subjectdrug toxicityen_US
dc.subjectsub-Saharan Africaen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleComparative incidence of adverse drug reactions during the first and subsequent year of antiretroviral therapy in a Nigeria HIV infected cohorten_US
dc.typeArticleen_US
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