Directed metalation of pyridinesulphonamides. Synthesis of pyridine‐fused isothiazoles and 1,2‐oxathioles

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dc.contributor.authorAlo, B.I.
dc.contributor.authorFamiloni, O.B.
dc.contributor.authorMarsais, F.
dc.contributor.authorQueguiner, G.
dc.date.accessioned2019-08-31T10:42:18Z
dc.date.available2019-08-31T10:42:18Z
dc.date.issued1992-01
dc.description.abstract4‐Lithio‐N‐t‐butylpyridine‐3‐sulphonamide reacted with benzophenone and carbon dioxide respectively to give the corresponding intermediates which on appropriate treatment gave isothiazolo[5,4‐c]pyridin‐3‐one 1,1‐dioxides. Metalation of 2‐ and 4‐(N,N‐dialkylaminosulphonyl)pyridines with lithium diisopropylamide (LDA) gave anions which reacted with benzophenone to give carbinols which thermally cyclised to 1,2‐oxathiolo[3,4‐b]pyridine and 1,2‐oxathiolo[4,3‐c]pyridine respectively.en_US
dc.identifier.citationAlo, B. I., Familoni, O. B., Marsais, F., & Queguiner, G. (1992). Directed metalation of pyridinesulphonamides. Synthesis of pyridine‐fused isothiazoles and 1, 2‐oxathioles. Journal of heterocyclic chemistry, 29(1), 61-64.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4930
dc.language.isoenen_US
dc.publisherJournal of Heterocyclic Chemistryen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistryen_US
dc.subjectMetalationen_US
dc.subjectcarbinolsen_US
dc.titleDirected metalation of pyridinesulphonamides. Synthesis of pyridine‐fused isothiazoles and 1,2‐oxathiolesen_US
dc.typeArticleen_US
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