Characterization of Mangifera indica linn (family: Anacardiaceae.) seed endosperm gum for potential application as pharmaceutical excipient

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dc.contributor.authorOlogunagba, M.O.
dc.contributor.authorAzubuike, C.P.
dc.contributor.authorSilva, B.O.
dc.contributor.authorLadanu, O.
dc.date.accessioned2020-02-24T10:33:10Z
dc.date.available2020-02-24T10:33:10Z
dc.date.issued2018
dc.descriptionStaff publicationsen_US
dc.description.abstractNatural products are increasingly used as excipients in formulation systems over the synthetics because of their comparative advantages. This study was aimed at the characterization of Mangifera indica seed gum (MisG) extracted from its endosperm using microwave-assisted technique. Physiochemical, pharmacognostic, microbial load were carried out using established methods and standard protocols. The yield of MisG was 15.63 ± 0.05% w/w. Physicochemical analysis revealed that MisG had particle size of 115.00 ± 0.12 μm, moisture content of 10.15 ± 0.11%, pH of 6.20 ±0.03, swelling index of 2.27 ± 0.09, water binding capacity 112.0 ± 0.1%, viscosity of 1.1 ± 0.2cP, flow rate of 3.01 ± 0.09 g/sec, bulk density of 0.51 ± 0.01 g/cm3, tapped density of 0.63 ± 0.01 g/cm3, Hausner’s ratio of 1.23±0.03, compressibility index of 19.10 ±0.03 and angle of repose of 29.35°. Microbial evaluation revealed the absence of objectionable microorganisms while the total aerobic microbial and yeast and mould counts were 1.20x102 and 11.50 x101 respectively. These values did not exceed the microbial limits specified by the United States Pharmacopoeia. These desirable physicochemical, pharmacognostical and microbial properties suggest that MisG could have good excipient potentials in pharmaceutical formulations.en_US
dc.identifier.citationOlogunagba, M. O., Azubuike, C. P., Silva, B. O., & Ladanu, O. T (2018). Characterization of Mangifera indica linn (family: Anacardiaceae.) seed endosperm gum for potential application as pharmaceutical excipient. Unilag Journal of Medicine, Science and Technology, 6(2), 175-184.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7818
dc.language.isoenen_US
dc.publisherUniversity of Lagosen_US
dc.relation.ispartofseriesUnilag Journal of Medicine, Science and Technology;Vol.6(2)
dc.subjectMangifera indica seed gumen_US
dc.subjectCharacterizationsen_US
dc.subjectExcipient potentialen_US
dc.subjectNatural productsen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleCharacterization of Mangifera indica linn (family: Anacardiaceae.) seed endosperm gum for potential application as pharmaceutical excipienten_US
dc.typeArticleen_US
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