Cognitive dysfunction in Nigerians with Parkinson's disease.

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dc.contributor.authorAkinyemi, R.O.
dc.contributor.authorOkubadejo, N.U.
dc.contributor.authorAkinyemi, J.O.
dc.contributor.authorOwolabi, M.O.
dc.contributor.authorOwolabi, L.F.
dc.contributor.authorOgunniyi, A.
dc.date.accessioned2019-11-02T14:34:01Z
dc.date.available2019-11-02T14:34:01Z
dc.date.issued2008-07-30
dc.description.abstractDespite the original description of Parkinson's disease (PD) as a disorder in which "the senses and intellect remain uninjured," there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI'D') and selected items from the Ibadan Neuropsychological Battery (I-NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI'D' score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08-1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD.en_US
dc.identifier.citationAkinyemi RO, Okubadejo NN, Akinyemi JO, Owolabi MO, Owolabi LF, Ogunniyi A. Cognitive dysfunction in Nigerians with Parkinson's disease. Mov Disord. 2008 Jul 30;23(10):1378-83.en_US
dc.identifier.otherdoi: 10.1002/mds.22087.
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6665
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectParkinson diseaseen_US
dc.subjectCognitive dysfunctionen_US
dc.subjectSeverityen_US
dc.subjectNigeriaen_US
dc.subjectAfricaen_US
dc.titleCognitive dysfunction in Nigerians with Parkinson's disease.en_US
dc.typeArticleen_US
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