Ecofriendly Synthesis in Aqueous Medium: An Expeditious Approach to New N,N-Diethyl Amide Bearing Benzenemethanesulfonamides
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An highly expeditious synthetic approach for the synthesis of benzenemethanesulfonamides (1a-k) and their new corresponding N,N-diethyl substituted amido moieties (2a-k) has been achieved in aqueous medium at room temperature. The reaction condition was thoroughly optimized thereby allowing significant rate enhancement and resulting into excellent yields. The chemical structures of the successful candidates were confirmed using elemental analytical and spectroscopic data such as IR, 1 H NMR, 13C NMR and some selected mass spectral data.
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesis , sulfonamide , amino acids , spectroscopy , sulfonylation
Ajani, O. O., Familoni, O. B., Echeme, J. O., & Wu, F. (2013). Ecofriendly Synthesis in Aqueous Medium: An Expeditious Approach to New N, N-Diethyl Amide Bearing Benzenemethanesulfonamides. The Open Organic Chemistry Journal, 7, 1-10.