Genome-wide search for susceptibility genes to type 2 diabetes in West Africans: Potential role of C-peptide

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dc.contributor.authorChen, G
dc.contributor.authorAdeyemo, A
dc.contributor.authorZhou, J
dc.contributor.authorChen, Y
dc.contributor.authorHuang, H
dc.contributor.authorDoumatey, A
dc.contributor.authorLashley, K
dc.contributor.authorAgyenim-Boateng, K
dc.contributor.authorEghan, B.A Jr
dc.contributor.authorAcheampong, J
dc.contributor.authorFasanmade, O
dc.contributor.authorJohnson, T
dc.contributor.authorOkafor, G
dc.contributor.authorOli, J
dc.contributor.authorAmoah, A
dc.contributor.authorRotimi, C
dc.date.accessioned2019-12-13T13:54:06Z
dc.date.available2019-12-13T13:54:06Z
dc.date.issued2007-12
dc.descriptionStaff publicationsen_US
dc.description.abstractC-peptide is a substance that the pancreas releases into the circulation in equimolar amounts to insulin and has demonstrated important physiological effects which relate to the vascular field, in particular the microcirculation. For this analysis, we included 321 full and 36 half sibling pairs affected with type 2 diabetes (T2D) from West Africa. A genome-wide panel of 390 tri-nucleotide and tetra-nucleotide repeats with an average distance of 8.9 cM was performed on a total of 691 persons. Variance components based on multipoint linkage approach as implemented in SOLAR were performed for log C-peptide. Significant linkage evidences were observed on 10q23 at D10S2327 with a LOD score of 4.04 (nominal p-value = 0.000008, empirical p-value = 0.0004); and on 4p15 at D4S2632 with a LOD score of 3.48 (nominal p-value = 0.000031, empirical p-value = 0.0013). Other suggestive evidence of linkage were observed on 15q14 at D15S659 with a LOD score 2.41 (nominal p-value = 0.000435, empirical p-value = 0.0068), and on 18p11 near D18S976 with a LOD score 2.18 (nominal p-value = 0.000771 and empirical p-value = 0.0094). Interestingly, five positional candidate genes for diabetes and related complications are located in our linkage region (the pituitary adenylate cyclase activating polypeptide (PACAP in 18p11); the peroxisome proliferator-activated receptor gamma coactivator 1 (PPARGC1 in 4p15); PTEN, PPP1R5, and IDE located in 10q23. In conclusion, we identified four major genetic loci (10q23, 4p15, 15q14, and 18p11) influencing C-peptide concentration in West Africans with T2D.en_US
dc.identifier.citationChen G, Adeyemo A, Zhou J, Chen Y, Huang H, Doumatey A, Lashley K, Agyenim-Boateng K, Eghan BA Jr, Acheampong J, Fasanmade O, Johnson T, Okafor G, Oli J, Amoah A, Rotimi C. Genome-wide search for susceptibility genes to type 2 diabetes in West Africans: Potential role of C-peptide. Diabetes Res Clin Pract. 2007 Dec;78(3):e1-6.Diabetes Res Clin Pract. 2007 Dec;78(3):e1-6. Epub 2007 Jun 4en_US
dc.identifier.issn01688227
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7103
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesDiabetes Res Clin Pract;Vol.78(3)
dc.subjectC-peptideen_US
dc.subjectGenome scanen_US
dc.subjectWest Africaen_US
dc.subjectType 2 diabetesen_US
dc.titleGenome-wide search for susceptibility genes to type 2 diabetes in West Africans: Potential role of C-peptideen_US
dc.typeArticleen_US
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