Characterization and Disintegrant Potential of Phosphorylated Tiger Nut (Cyperus esculentus) Starch in Immediate Release Ibuprofen Tablet Formulation

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dc.contributor.authorOnwuatuegwu, O
dc.contributor.authorAzubuike, C
dc.contributor.authorAloko, S
dc.contributor.authorOlogunagba, M
dc.contributor.authorIgwilo, C
dc.date.accessioned2019-11-26T08:44:19Z
dc.date.available2019-11-26T08:44:19Z
dc.date.issued2019-06
dc.descriptionStaff publicationsen_US
dc.description.abstractThe study was aimed at evaluating the physicochemical properties of phosphorylated tiger nut starch (TNP) and its disintegrant properties in immediate release ibuprofen tablets. Native tiger nut starch (TNS) was modified by phosphorylation with disodium hydrogen orthophosphate at 130oC and its physicochemical properties were evaluated. Ibuprofen tablets were formulated with TNP and sodium starch glycolate (SSG) at concentrations of 5.0, 7.5, 10.0 and 15.0% as disintegrants. Phosphorylation of TNS led to improved flow properties and swelling and hydration capacities among other changes in the physicochemical properties. TNP had comparable properties with SSG. FTIR study confirmed modification and also showed that TNP is compatible with ibuprofen powder. Ibuprofen tablets produced with TNP as disintegrant had acceptable tablet properties comparable to those produced with SSG. The disintegrant potential improved with increased concentration of TNP. The results indicate that TNP has a promising disintegrant potential in tablet formulations.en_US
dc.identifier.citationOnwuatuegwu, O., Azubuike, C., Aloko, S., Ologunagba, M., & Igwilo, C. (2019). Characterization and Disintegrant Potential of Phosphorylated Tiger Nut (Cyperus esculentus) Starch in Immediate Release Ibuprofen Tablet Formulation. Dhaka University Journal of Pharmaceutical Sciences, 18(1), 21-29. https://doi.org/10.3329/dujps.v18i1.41423en_US
dc.identifier.otherhttps://doi.org/10.3329/dujps.v18i1.41423
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6969
dc.language.isoenen_US
dc.publisherBangladesh Journals Onlineen_US
dc.relation.ispartofseriesDhaka University Journal of Pharmaceutical Sciences;Vol.18(1)
dc.subjectCyperus escilentus starchen_US
dc.subjectPhosphorylationen_US
dc.subjectModified starchen_US
dc.subjectDisintegranten_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleCharacterization and Disintegrant Potential of Phosphorylated Tiger Nut (Cyperus esculentus) Starch in Immediate Release Ibuprofen Tablet Formulationen_US
dc.typeArticleen_US
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