Mass transport in arteries and the localization of atherosclerosis in human
Chaoyang University of Technology
Atherosclerosis is a disease of the large arteries that involves a characteristic accumulation of high-molecular weight lipoprotein in the arterial wall. This research focuses on the mass transport processes that mediate the focal accumulation of lipid in arteries and places particular emphasis on the role of fluid mechanical forces in modulating mass transport phenomena as well as analysis of the Damkholer numbers within the arterial surfaces. Blood phase controlled hypoxia was considered in the mass transport mechanisms emerge in the localization of atherosclerosis. The results of the analysis of Damkholer numbers indicated that there were no significant difference between the model derived values of the Damkholer numbers and the corresponding simulated values. Model values ( Dar = 17.7 for ATP , Dac = 0.02 − 1.0 for LDL, 0.027 − 0.10 for albumin, Daw = 10.8 − 49.0 for oxygen) and simulated value ( Dar = 7.762 for oxygen, Dac = 1.214 for LDL, Daw =14.58 for oxygen); where Dar is Damkholer number, Dac is Damkholer number based on endothelial permeability and Daw is Damkholer number based on the wall consumption. The flux of LDL into the arterial wall depends on the plasma concentration and permeability Pe which for human aorta, is between the range of 5×10−4 −2.5×10−3m/s. Thus, a correlation between Pe and plasma concentration enhances the localization of atherosclerotic plaques.
Transport, Artheroclerosis, Arteries, Accumulation, Lipoprotein
Gutti B, Susu AA, Fasanmade OA. Mass transport in arteries and the localization of atherosclerosis in human. International journal of engineering and applied sciences. 2010; 2(3):53-62