Testicular Dysfunction is a Common Feature in Men with Type 2 Diabetes Mellitus in a Nigerian Tertiary Hospital

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dc.contributor.authorOnung, S.I
dc.contributor.authorYoung, E.E
dc.contributor.authorFasanmade, O.A
dc.contributor.authorAnyanwu, A.C
dc.contributor.authorNwatu, B.C
dc.contributor.authorOhwovoriole, A.E
dc.date.accessioned2020-01-08T14:02:58Z
dc.date.available2020-01-08T14:02:58Z
dc.date.issued2018
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground: Hypogonadism in male patients with diabetes mellitus is associated with older age, obesity and poor glycaemic control. The patterns of sperm count, testicular volume, sperm motility and morphology have also been reported to be abnormal in these patients, though reports are conflicting. The objectives of this study were to assess gonadal function and sperm parameters in Nigerian males with diabetes mellitus. Methods: A study sample of 150 males consisting of 108 patients and 56 age-matched controls were recruited. The ADAM questionnaire was used to obtain a clinical score for hypogonadism. Laboratory parameters measured were fasting plasma glucose, serum LH, FSH, free testosterone, total cholesterol, LDL, HDL and triglyceride. Testicular volume was measured with a Prader orchidometer. Total sperm count, sperm morphology and motility were assessed. Results: Hypogonadism was present in 38.9% of males with diabetes compared to 3.6% in controls. The patients with diabetes had significantly lower sperm count, reduced sperm motility with increased abnormal forms than the controls (p<0.001, p<0.001). Only 8.5% of the patients did not demonstrate any abnormality in testicular function. Conclusion: Poor sperm function was more common than hypogonadism and was associated with poor glycaemic control (p<0.001). Likewise, hypogonadism was significantly associated with poor glycaemic control (p<0.001).en_US
dc.identifier.citationOnung SI, Young EE, Fasanmade OA, Anyanwu AC, Nwatu BC, Ohwovoriole AE. Testicular Dysfunction is a Common Feature in Men with Type 2 Diabetes Mellitus in a Nigerian Tertiary Hospital. Current Diabetes Reviews, Vol.14(3), 2018, pp. 298-306(9)en_US
dc.identifier.issn15733998
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7327
dc.language.isoenen_US
dc.publisherBentham Science publishersen_US
dc.relation.ispartofseriesCurrent Diabetes Reviews;Vol.14(3)
dc.subjectMalesen_US
dc.subjectSperm functionen_US
dc.subjectType 2 diabetesen_US
dc.subjectHypogonadismen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleTesticular Dysfunction is a Common Feature in Men with Type 2 Diabetes Mellitus in a Nigerian Tertiary Hospitalen_US
dc.typeArticleen_US
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