Chemical Composition, Gastroprotective, and Antioxidant Activities of Schrebera arborea Fruits

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dc.contributor.authorSofidiya, M.O.
dc.contributor.authorBamigbade, O.
dc.contributor.authorBasheeru, K.
dc.contributor.authorAdegoke, O.
dc.contributor.authorAgunbiade, FO
dc.date.accessioned2022-01-16T19:54:04Z
dc.date.available2022-01-16T19:54:04Z
dc.date.issued2020-01-02
dc.description.abstractThe chemical composition, gastroprotective, and antioxidant activities of Schrebera arborea fruits were investigated. The solvent extracts were analyzed for fatty acid and polyphenolic content using gas chromatography-mass spectrometry (GC–MS) and high performance liquid chromatography (HPLC), respectively. Acute toxicity study was done by oral administration at 2,000 mg kg–1. Gastroprotective effect was evaluated at 50, 100, or 150 mg kg–1 in ethanol and indomethacin-induced ulcer models in rats. The antioxidant activities of the extract were also evaluated. Sitosterol (41.55%) was the major component identified by GC–MS. Quantitative HPLC analysis for phenolic compounds indicated the presence of gallic acid (0.19 mg g–1), caffeic acid (0.13 mg g–1), rutin (0.30 mg g–1), apigenin-7-glucoside (1.21 mg g–1), catechin (1.84 mg g–1), and kaempferol (6.53 mg g–1), respectively. The ethanolic extract of the fruit produced 63.5% and 80.8% inhibition of ethanol and indomethacin-induced ulcer at 100 mg kg–1, respectively. The extract at 100 mg kg–1 reduced MDA level and increased glutathione, catalase, and superoxide dismutase activities in rat stomach tissue. Significant radical scavenging antioxidant activity was recorded in vitro.en_US
dc.description.sponsorshipSelfen_US
dc.identifier.urihttps://doi.org/10.1080/10496475.2019.1679691
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10463
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.subjectHerbsen_US
dc.subjectChemical profileen_US
dc.subjectFruitsen_US
dc.titleChemical Composition, Gastroprotective, and Antioxidant Activities of Schrebera arborea Fruitsen_US
dc.typeArticleen_US
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