Suppressive, Curative, and Prophylactic Potentials of an Antimalarial Polyherbal Mixture and its Individual Components in Plasmodium berghei-Infected Mice.

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dc.contributor.authorAlaribe, S.C.
dc.contributor.authorOladipupo, A.R.
dc.contributor.authorGoodness, U.
dc.contributor.authorOnumba, U.
dc.contributor.authorOta, D.A.
dc.contributor.authorAwodele, O.
dc.contributor.authorOyibo, W.
dc.date.accessioned2022-09-13T10:53:34Z
dc.date.available2022-09-13T10:53:34Z
dc.date.issued2021
dc.descriptionScholarly articleen_US
dc.description.abstractEthnopharmacological relevance: Malaria remains one of the most prevalent infectious diseases in tropical regions of the world, particularly in sub-Saharan Africa, where it remains epidemiologically holoendemic. The absence of effective vaccines and Plasmodium resistance to antimalarial drugs have been the major challenges to malaria control measures. An alternative strategy could be the application of validated and standardized herbal formulations. Aim of the study: To evaluate the antimalarial activity of a polyherbal mixture (APM) and compare it to those of its individual constituent plants. Methods: APM consisted of stem barks of Mangifera indica (MI), Azadirachta indica (AI), Nauclea latifolia (and roots, NL) and roots of Morinda lucida (ML). Dihydroartemisinin-piperaquine (DHP) and pyronaridine artesunate (PA) served as positive controls. Antimalarial activity was evaluated using suppressive, curative and prophylactic assays in mice infected with Plasmodium berghei. Results: All the herbal mixtures, individually and in combination, showed significant (p < 0.05) antiplasmodial activities in the various assays. They produced considerable parasite suppression (>50%), substantial clearance (>70%), and notable prophylaxis (>60%, except for NL: 35%). APM (95.4–98.7%) and AI (92%), respectively, elicited greater and comparable suppression relative to DHP (88%) and PA (87.3%). However, all the herbal decoctions, individually (72–93.6%) and in combination (82.5–91%), showed lower parasite clearance than DHP (100%) and PA (99.5%). Meanwhile, APM showed relatively greater suppression and prophylaxis than its constituent plants, suggesting that the combination produced synergistic or additive effects. Conclusion: These findings could substantiate the use of these plants, singly or in combination, as traditional remedies for malaria. Further studies are recommended to evaluate their clinical usefulness.en_US
dc.identifier.citationAlaribe SC, Oladipupo AR, Uche GC, Onumba MU, Ota D, Awodele O, Oyibo WA. Suppressive, curative, and prophylactic potentials of an antimalarial polyherbal mixture and its individual components in Plasmodium berghei-Infected mice. J Ethnopharmacol. 2021 Sep 15;277:114105. doi: 10.1016/j.jep.2021.114105. Epub 2021 May 5. PMID: 33961995.en_US
dc.identifier.issndoi: 10.1016/j.jep.2021.114105
dc.identifier.issnISSN 0378-8741
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11469
dc.language.isoenen_US
dc.publisherJournal of Ethnopharmacology. doi: 10.1016/j.jep.2021.114105en_US
dc.subjectAntiplasmodial activity, Malaria, Chemosuppression, Malaria parasite clearance, Polyherbal decoction, Plasmodium bergheien_US
dc.subjectntiplasmodial activityen_US
dc.subjectMalariaen_US
dc.subjectChemosuppressionen_US
dc.subjectMalaria parasite clearanceen_US
dc.subjectPolyherbal decoctionen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleSuppressive, Curative, and Prophylactic Potentials of an Antimalarial Polyherbal Mixture and its Individual Components in Plasmodium berghei-Infected Mice.en_US
dc.typeArticleen_US
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