Microstructure characterization and thermal analysis of hybrid block copolymer α-methoxy-poly(ethylene glycol)-block-poly[ε-(benzyloxycarbonyl)-L-lysine] for biomedical applications
No Thumbnail Available
Date
2010
Authors
Izunobi, J. U.
Higginbotham, C. L.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Hybrid block copolymers, which combine the economy and processibility of synthetic polymers with the functionality and highly ordered structures of polypeptides, can enhance control over structure formation at the nanoscale, as well as afford interesting materials that interface with Nature for a diversity of biomedical applications, such as drug delivery, tissue engineering and bioimaging. Hybrid block copolymer, alpha-methoxy-poly(ethylene glycol)-block-poly[epison-(benzyloxycarbonyl)-L-lysine], MPEG-b-PLL(Z), was synthesized by anionic ring-opening polymerization in excellent yield, and fully characterized using IR, 1H, 13C and 2-D NMR, GPC, TGA, DTGA, DSC, MDSC and polarimetry. Its precursor NCA, epison-(benzyloxycarbonyl)-L-lysine N-carboxyanhydride, L-Lys(Z)-NCA, was prepared in 97% yield; and a double doublet
observed in the 1850–1750 cm-1 absorption region of its infrared spectrum, for the characteristic NCA carbonyl absorption bands, is discussed.
Description
Staff Publications
Keywords
Ring-opening Polymerization , Diblock Copolymers , Spectroscopy , Biopolymers , Research Subject Categories::NATURAL SCIENCES
Citation
Izunobi, J.U and Higginbotham, C.L (2010). Microstructure characterization and thermal analysis of hybrid block copolymer α-methoxy-poly(ethylene glycol)-block-poly[ε-(benzyloxycarbonyl)-L-lysine] for biomedical applications. Journal of Molecular Structure, Vol.977(1-3),153-164pp.