Self assembly of star shaped amphiphiles – Opportunities for drug delivery

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dc.contributor.authorAluko, O.M.
dc.date.accessioned2022-01-10T11:25:05Z
dc.date.available2022-01-10T11:25:05Z
dc.date.issued2010-09
dc.descriptionA thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Drug Delivery, University of Londonen_US
dc.description.abstractIn order to study the influence of branching on the self-assembly of PEG amphiphiles, polyethylene glycol (PEG)-based star-shaped have been synthesised and studied as self-assembling systems. Palmitoyl (C16) groups were grafted to 8-armed PEG with differing degrees of palmitoylation (P8PEG1 & P8PEG4). A novel amphiphilic linear analogue (HDPEG) was also synthesised with hexadecyl (C16) pendant groups for comparison. These amphiphiles were characterised using 1H Nuclear Magnetic Resonance, Fourier Transform- Infrared and MALDI-TOF mass spectroscopy. The Pyrene probe was employed to evaluate self assembly properties while Photon Correlation Spectroscopy was used to measure particle size distribution. Molecular architecture and hydrophobic substitution had a profound effect on their self-assembly behavior; as P8PEG4 with branched architecture and the greatest degree of hydrophobic substitution had the lowest polydispersity index. Also, the critical micellar concentration (CMC) for P8PEG4, P8PEG1 and HDPEG were 3, 8 and 15 μM respectively, inferring greater micelle stability with branched architecture and increased hydrophobic substitution. Particle size and morphology were confirmed by Transmission electron microscopy as P8PEG4 and HDPEG formed mixtures of micelles and nanoparticles while a novel core-shell nano- and micro self assembly was observed for P8PEG1. Preliminary drug encapsulation studies on the amphiphiles loaded low amounts of Griseofulvin (0.04-0.09mg/ml with 5mg/ml of polymers). These resulting stable aggregates of PEG-based amphiphiles may be of benefit for drug delivery applications. However, future studies should focus on influence of polymer architecture on drug encapsulation in order to improve their encapsulation efficiency.en_US
dc.identifier.citationAluko, O.M. (2010). Self assembly of star shaped amphiphiles – Opportunities for drug delivery. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Drug Delivery, University of London. 94p.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10059
dc.language.isoenen_US
dc.publisherDepartment of Pharmaceutics The School of Pharmacy University of Londonen_US
dc.subjectPEG amphiphilesen_US
dc.subjectAmphiphilesen_US
dc.subjectPolyethylene glycol (PEG)en_US
dc.subjectEncapsulationen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleSelf assembly of star shaped amphiphiles – Opportunities for drug deliveryen_US
dc.typeThesisen_US
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