A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans. The Africa America Diabetes Mellitus (AADM) Study

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Rotimi, C.N
Chen, G
Adeyemo, A.A
Fubert-Harris, P
Osotimehin, B
Fasanmade, O
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American Diabetes Association
The incidence of type 2 diabetes is growing rapidly, not only in developed countries but also worldwide. We chose to study type 2 diabetes in West Africa, where diabetes is less common than in the U.S., reasoning that in an environment where calories are less abundant, incident cases of type 2 diabetes might carry a propor- tionately greater genetic component. Through the Af- rica America Diabetes Mellitus (AADM) study, we carried out a genome-wide linkage analysis of type 2 diabetes in a cohort of 343 affected sibling pairs (691 individuals) enrolled from five West African centers in two countries (Ghana: Accra and Kumasi; Nigeria: Enugu, Ibadan, and Lagos). A total of 390 polymorphic markers were genotyped, and multipoint linkage analy- sis was conducted using the GENEHUNTER-PLUS and ASM programs. Suggestive evidence of linkage was ob- served in four regions on three chromosomes (12, 19, and 20). The two largest logarithm of odds scores of 2.63 and 1.92 for chromosomes 20q13.3 and 12q24, respectively, are particularly interesting because these regions have been reported to harbor diabetes suscep- tibility genes in several other populations and ethnic groups. Given the history of forced migration of West African populations during the slave trade, these re- sults should have considerable relevance to the study of type 2 diabetes in African Americans.
Diabetes, susceptibility genes, genome wide scan, AADM
Rotimi CN, Chen G, Adeyemo AA, Fubert-Harris P, Guass D, Zhou J, Berg K, Adegoke O, Amoah A, Owusu S, Acheampong J, Agyenim-Boateng K, Eghan BA, Oli J, Okafor G, Ofoegbu E, Osotimehin B, Abbiyesuku F, Johnson T, Rufus T, Fasanmade O, Kittles R, Daniel H, Chen Y, Dunston G, Collins FS. A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans The Africa America Diabetes Mellitus (AADM) Study. Diabetes. 2004 Mar;53(3):838-41. Erratum in: Diabetes. 2004 May;53(5):1404. Guass, Debra [corrected to Parish-Gause, Debra