The value of percentage free prostate specific antigen (PSA) in the detection of prostate cancer among patients with intermediate levels of total PSA (4.0–10.0 ng/mL) in Nigeria

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dc.contributor.authorEzenwa, E.V.
dc.contributor.authorTijani, K.H.
dc.contributor.authorJeje, E.A.
dc.contributor.authorSoriyan, O.O.
dc.contributor.authorOgunjimi, M.A.
dc.contributor.authorOjewola, R.W.
dc.contributor.authorAjie, O.I.
dc.contributor.authorEl-Nahas, A.R.
dc.date.accessioned2020-02-25T08:39:03Z
dc.date.available2020-02-25T08:39:03Z
dc.date.issued2012-07-12
dc.descriptionStaff publicationsen_US
dc.description.abstractAbstract Objectives: To assess the value of percentage free prostate-specific antigen (%fPSA) in the detection of prostate cancer among Nigerian men with an intermediate total PSA level (4–10 ng/mL), and to show if the optimum threshold for biopsy is different from Caucasian values when the widely used (six-core, digitally directed) prostate biopsy protocol in Nigerians is applied. Patients and methods: The study included 105 patients aged >50 years, with a palpably benign prostate gland and intermediate levels of total PSA (4–10 ng/mL). These patients had a free PSA assay and a transrectal digitally directed six-core biopsy of the prostate. The %fPSA was calculated and the optimum threshold value for detecting prostate cancer was determined. Results: The mean (SD) age of the patients was 64.4 (6.6) years and their mean (SD) total PSA level was 6.6 (1.7) ng/mL. Of these men 14 (13.3%) had cancer of the prostate detected by the prostate biopsy. The %fPSA level related directly to sensitivity values but inversely to the specificity and the positive predictive values. The best threshold of %fPSA for detecting cancer in these men was <40%, with a sensitivity of 100%, specificity of 93.4% and a positive predictive value of 70% (P<0.05). Conclusions: In evaluating Nigerian patients with a palpably benign prostate gland and within the intermediate total PSA range, when digitally directed biopsy protocol is adopted, a %fPSA threshold of <40% will detect significant percentage of those with prostate cancer, with a minimal number of unnecessary biopsies. This value differs from that reported in western studies in which transrectal ultrasonography- directed biopsy was used.en_US
dc.identifier.citationEzenwa E.V., Tijani K.H., Jeje E.A., Soriyan O.O., Ogunjimi M.A., Ojewola R.W., Ajie O.I., El-Nahas A.R.The value of percentage free prostate specific antigen (PSA) in the detection of prostate cancer among patients with intermediate levels of total PSA (4.0-10.0 ng/mL) in Nigeria. Arab J Urol. 2012 Dec;10(4):394-400.en_US
dc.identifier.otherdoi: 10.1016/j.aju.2012.05.004. Epub 2012 Jul 12.
dc.identifier.otherPMID: 26558056
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7852
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesArab J Urol.;Vol.10(4)
dc.subjectFree PSAen_US
dc.subjectIntermediate PSA rangeen_US
dc.subjectNigeriaen_US
dc.subjectProstate canceren_US
dc.subjectResearch Subject Categories::MEDICINE::Surgeryen_US
dc.titleThe value of percentage free prostate specific antigen (PSA) in the detection of prostate cancer among patients with intermediate levels of total PSA (4.0–10.0 ng/mL) in Nigeriaen_US
dc.typeArticleen_US
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