The value of percentage free prostate specific antigen (PSA) in the detection of prostate cancer among patients with intermediate levels of total PSA (4.0–10.0 ng/mL) in Nigeria
dc.contributor.author | Ezenwa, E.V. | |
dc.contributor.author | Tijani, K.H. | |
dc.contributor.author | Jeje, E.A. | |
dc.contributor.author | Soriyan, O.O. | |
dc.contributor.author | Ogunjimi, M.A. | |
dc.contributor.author | Ojewola, R.W. | |
dc.contributor.author | Ajie, O.I. | |
dc.contributor.author | El-Nahas, A.R. | |
dc.date.accessioned | 2020-02-25T08:39:03Z | |
dc.date.available | 2020-02-25T08:39:03Z | |
dc.date.issued | 2012-07-12 | |
dc.description | Staff publications | en_US |
dc.description.abstract | Abstract Objectives: To assess the value of percentage free prostate-specific antigen (%fPSA) in the detection of prostate cancer among Nigerian men with an intermediate total PSA level (4–10 ng/mL), and to show if the optimum threshold for biopsy is different from Caucasian values when the widely used (six-core, digitally directed) prostate biopsy protocol in Nigerians is applied. Patients and methods: The study included 105 patients aged >50 years, with a palpably benign prostate gland and intermediate levels of total PSA (4–10 ng/mL). These patients had a free PSA assay and a transrectal digitally directed six-core biopsy of the prostate. The %fPSA was calculated and the optimum threshold value for detecting prostate cancer was determined. Results: The mean (SD) age of the patients was 64.4 (6.6) years and their mean (SD) total PSA level was 6.6 (1.7) ng/mL. Of these men 14 (13.3%) had cancer of the prostate detected by the prostate biopsy. The %fPSA level related directly to sensitivity values but inversely to the specificity and the positive predictive values. The best threshold of %fPSA for detecting cancer in these men was <40%, with a sensitivity of 100%, specificity of 93.4% and a positive predictive value of 70% (P<0.05). Conclusions: In evaluating Nigerian patients with a palpably benign prostate gland and within the intermediate total PSA range, when digitally directed biopsy protocol is adopted, a %fPSA threshold of <40% will detect significant percentage of those with prostate cancer, with a minimal number of unnecessary biopsies. This value differs from that reported in western studies in which transrectal ultrasonography- directed biopsy was used. | en_US |
dc.identifier.citation | Ezenwa E.V., Tijani K.H., Jeje E.A., Soriyan O.O., Ogunjimi M.A., Ojewola R.W., Ajie O.I., El-Nahas A.R.The value of percentage free prostate specific antigen (PSA) in the detection of prostate cancer among patients with intermediate levels of total PSA (4.0-10.0 ng/mL) in Nigeria. Arab J Urol. 2012 Dec;10(4):394-400. | en_US |
dc.identifier.other | doi: 10.1016/j.aju.2012.05.004. Epub 2012 Jul 12. | |
dc.identifier.other | PMID: 26558056 | |
dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/7852 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartofseries | Arab J Urol.;Vol.10(4) | |
dc.subject | Free PSA | en_US |
dc.subject | Intermediate PSA range | en_US |
dc.subject | Nigeria | en_US |
dc.subject | Prostate cancer | en_US |
dc.subject | Research Subject Categories::MEDICINE::Surgery | en_US |
dc.title | The value of percentage free prostate specific antigen (PSA) in the detection of prostate cancer among patients with intermediate levels of total PSA (4.0–10.0 ng/mL) in Nigeria | en_US |
dc.type | Article | en_US |