Insulin Resistance In Semi-Urban South Western Nigeria And It’s Relationship With Indices Of Obesity

dc.contributor.authorRaimi, T.H
dc.contributor.authorOdusan, O.O
dc.contributor.authorFasanmade, O.A
dc.contributor.authorOdewabi, A.O
dc.contributor.authorAjala, M.O
dc.contributor.authorOritogun, K
dc.date.accessioned2020-01-17T13:52:48Z
dc.date.available2020-01-17T13:52:48Z
dc.date.issued2012
dc.descriptionStaff publicationsen_US
dc.description.abstractThe International Diabetes Federation (IDF) estimates that currently more than 246 million people have diabetes worldwide, and this figure is expected to reach 380 million by 2030. Although insulin resistance is a modifiable precursor of diabetes and potentially of cardiovascular disease, there are scanty reports on its prevalence in Nigeria. The aim of this study was to determine the prevalence of insulin resistance and its relationship within dices of obesity in a semi urban Nigeria. Fifty subjects with no prior history of hypertension or diabetes mellitus were evaluated for insulin resistance using the homeostasis model assessment (HOMA) method. The blood pressure and the anthropometric parameters of the subjects were measured, and fasting plasma glucose andinsulin determined. Insulin resistance was defined at two levels of HOMA scores: score >1 and score >2 and its correlation with waist circumference, body mass index and waist to hip ratio were determined. When insulin resistance was defined as HOMA score >1, the prevalence of insulin resistance was 29.2% in males and 53.8% infemales (p>0.05), with a combined prevalence of 42%. When insulin resistance was taken as HOMA score >2 the females were significantly more resistant to insulin than the males (females 38.5% vs 12.5%, p <0.05), and thecombined prevalence was 26%. There was positive but weak correlation between the anthropometric indices and insulin resistance. The correlation between insulin resistance and the anthropometric indices was best with waist circumference, while it was least with waist-to-hip ratio (0.181 vs. 0.081). Of the three indices of obesity, waist circumference contributed most to HOMA-IR. Insulin resistance is common in the South Western Nigerian population studied, and insulin resistance was more prevalent among the female than male participants. There was a positive but weak correlation between insulin resistance and anthropometric indices.Key Words: insulin resistance, HOMA-IR, obesityen_US
dc.identifier.citationRaimi TH, Odusan OO, Fasanmade OA, Odewabi AO, Ajala MO, Oritogun K et al. Insulin Resistance In Semi-Urban South Western Nigeria And It’s Relationship With Indices Of Obesity. Nigerian Endocrine Practice 2012;6(2)en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7433
dc.language.isoenen_US
dc.publisherNigerian chapter of American association of clinical endocrinologistsen_US
dc.relation.ispartofseriesNigerian Endocrine Practice;Vol.6(2)
dc.subjectInsulin resistance, South western Nigeria, HOMA, obesityen_US
dc.subjectInsulin resistanceen_US
dc.subjectSouth western Nigeriaen_US
dc.subjectHOMAen_US
dc.subjectObesityen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleInsulin Resistance In Semi-Urban South Western Nigeria And It’s Relationship With Indices Of Obesityen_US
dc.typeArticleen_US
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