Genomic analyses in African populations identify loci for cleft palate

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dc.contributor.authorButali, A.
dc.contributor.authorMossey, P.A.
dc.contributor.authorAdeyemo, W.L.
dc.contributor.authorEshete, M.A.
dc.contributor.authorGowans, L.J.J.
dc.contributor.authorBusch, T.
dc.contributor.authorJain, D.
dc.contributor.authorYu, W.
dc.contributor.authorHuan, L.
dc.contributor.authorLaurie, C.C.
dc.contributor.authorLaurie, C.A.
dc.contributor.authorNelson, S.
dc.contributor.authorLi, M.
dc.contributor.authorSanchez-Lara, P.A.
dc.contributor.authorMagee, W.P.
dc.contributor.authorMagee, K.S.
dc.contributor.authorAuslander, A.
dc.contributor.authorBrindopke, F.
dc.contributor.authorKay, D.M.
dc.contributor.authorCaggana, M.
dc.contributor.authorRomitti, P.A.
dc.contributor.authorMills, J.L.
dc.contributor.authorAudu, R.
dc.contributor.authorOnwuamah, C.
dc.contributor.authorOseni, G.O.
dc.contributor.authorOwais, A.
dc.contributor.authorJames, O.
dc.contributor.authorOlaitan, P.B.
dc.contributor.authorAregbesola, B.S.
dc.contributor.authorBraimah, R.O.
dc.contributor.authorOginni, F.O.
dc.contributor.authorOladele, A.O.
dc.contributor.authorBello, S.A.
dc.contributor.authorRhodes, J.
dc.contributor.authorShiang, R.
dc.contributor.authorDonkor, P.
dc.contributor.authorObiri-Yeboah, S.
dc.contributor.authorArthur, F.K.N.
dc.contributor.authorTwumasi, P.
dc.contributor.authorAgbenorku, P.
dc.contributor.authorPlange-Rhule, G.
dc.contributor.authorOti, A.
dc.contributor.authorOgunlewe, M.O.
dc.contributor.authorOladega, A.A.
dc.contributor.authorAdekunle, A.A.
dc.contributor.authorErinoso, A.O.
dc.contributor.authorAdamson, O.O.
dc.contributor.authorElufowoju, A.A.
dc.contributor.authorAyelomi, O.I.
dc.contributor.authorHailu, T.
dc.contributor.authorHailu, A.
dc.contributor.authorDemissie, Y.
dc.contributor.authorDerebew, M.
dc.contributor.authorEliason, S.
dc.contributor.authorRomero-Bustillous, M.
dc.contributor.authorLo, C.
dc.contributor.authorPark, J.
dc.contributor.authorDesai, S.
dc.contributor.authorMohammed, M.
dc.contributor.authorAbate, F.
dc.contributor.authorAbdur-Rahman, L.O.
dc.contributor.authorAnand, D.
dc.contributor.authorSaadi, I.
dc.contributor.authorOladugba, A.V.
dc.contributor.authorLachke, S.A.
dc.contributor.authorAmendt, B.A.
dc.contributor.authorRotimi, C.N.
dc.contributor.authorMarazita, M.L.
dc.contributor.authorCornell, R.A.
dc.contributor.authorMurray, J.C.
dc.contributor.authorAdeyemo, A.A.
dc.date.accessioned2019-10-30T08:03:26Z
dc.date.available2019-10-30T08:03:26Z
dc.date.issued2019-03-15
dc.descriptionStaff publicationsen_US
dc.description.abstractOrofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with ~17 million markers in sub-Saharan Africans. After replication and combined analyses, we identified novel loci for CPO at or near genome-wide significance on chromosomes 2 (near CTNNA2) and 19 (near SULT2A1). In situ hybridization of Sult2a1 in mice showed expression of SULT2A1 in mesenchymal cells in palate, palatal rugae and palatal epithelium in the fused palate. The previously reported 8q24 was the most significant locus for CL/P in our study, and we replicated several previously reported loci including PAX7 and VAX1.en_US
dc.identifier.citationButali A, Mossey PA, Adeyemo WL, Eshete MA, Gowans LJ, Busch TD, Jain D, Yu W, Huan L, Laurie CA, Laurie CC, Nelson S, Li M, Sanchez-Lara PA, Magee WP 3rd, Magee KS, Auslander A, Brindopke F, Kay DM, Caggana M, Romitti PA, Mills JL, Audu R, Onwuamah C, Oseni GO, Owais A, James O, Olaitan PB, Aregbesola BS, Braimah RO, Oginni FO, Oladele AO, Bello SA, Rhodes J, Shiang R, Donkor P, Obiri-Yeboah S, Arthur FKN, Twumasi P, Agbenorku P, Plange-Rhule G, Oti AA, Ogunlewe OM, Oladega AA, Adekunle AA, Erinoso AO, Adamson OO, Elufowoju AA, Ayelomi OI, Hailu T, Hailu A, Demissie Y, Derebew M, Eliason S, Romero-Bustillous M, Lo C, Park J, Desai S, Mohammed M, Abate F, Abdur-Rahman LO, Anand D, Saadi I, Oladugba AV, Lachke SA, Amendt BA, Rotimi CN, Marazita ML, Cornell RA, Murray JC, Adeyemo AA. Genomic analyses in African populations identify loci for cleft palate. Human Mol Genet. 2019;28: 1038-1051.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6605
dc.language.isoenen_US
dc.publisherOxford Academicen_US
dc.subjectGWASen_US
dc.subjectNovel risken_US
dc.subjectAfrican populationsen_US
dc.subjectLocien_US
dc.subjectAfrican populationen_US
dc.subjectCleft palateen_US
dc.subjectResearch Subject Categories::ODONTOLOGYen_US
dc.titleGenomic analyses in African populations identify loci for cleft palateen_US
dc.typeArticleen_US
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