Synthesis and Biological Activity of Copper(Ii) Schiff Base Complexes as Potential Agents for Tuberculosis Therapy

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dc.contributor.authorDueke-Eze, C.U.
dc.contributor.authorFasina, T.M.
dc.contributor.authorFamiloni, O.B.
dc.contributor.authorOnubogu, C.C.
dc.contributor.authorMphahlele, M.J.
dc.date.accessioned2019-09-05T16:42:43Z
dc.date.available2019-09-05T16:42:43Z
dc.date.issued2015-03
dc.description.abstractFour new copper (II) Schiff base complexes (CuL1-CuL4) were synthesized by reaction of CuCl2.2H2O with Schiff bases L1-L4 derived from condensation of 2-aminopyridine with substituted saliclyaldehydes. The compounds were characterized by elemental analysis, infrared (IR), nuclear magnetic resonance (NMR), electronic absorption and molar conductivity. The Schiff bases reacted as bidentate ligands towards copper (II) to yield complexes with a 1:1 (M:L) molar ratio. Evaluation of the in-vitro anti-tuberculosis activity against mycobacterium tuberculosis H37RV using the proportion method showed the complexes exhibited enhanced invitro anti-tuberculosis activity against the bacteria compared to the free ligands and reference compound (INH).en_US
dc.identifier.citationDueke-Eze, C. U., Fasina, T. M., Familoni, O. B., Onubogu, C. C., & Mphahlele, M. J. (2017). Synthesis and Biological Activity of Copper (Ii) Schiff Base Complexes as Potential Agents for Tuberculosis Therapy. NISEB Journal, 15(1).en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5350
dc.language.isoenen_US
dc.publisherNigerian Society for Experimental Biology journalsen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry::Coordination chemistryen_US
dc.subject2-aminopyridineen_US
dc.subjectschiff baseen_US
dc.subjectCopper (II) complexesen_US
dc.subjectMycobacterium tuberculosisen_US
dc.titleSynthesis and Biological Activity of Copper(Ii) Schiff Base Complexes as Potential Agents for Tuberculosis Therapyen_US
dc.typeArticleen_US
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