Cushing's syndrome in a female with short stature: a case report

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Obijinmi, Boluwatife
Olopade, O.B
Odeniyi, I.A
Fasanmade, O.A
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Association of Clinical Endocrinologists of Nigeria
Cushing’s syndrome is a rare endocrine disorder that occurs when the body produces too much cortisol, a hormone that is produced by the adrenal glands. It results from chronic exposure to high levels of glucocorticoids. It can be caused by external sources such as glucocorticoid medication or internal factors such as an adrenal or pituitary gland tumour. When seen in children or adolescents, it tends to affect growth and development with a myriad of complications. AIM: A rare case of Cushing’s syndrome in a female Nigerian adolescent manifesting A 20-year-old female Nigerian diagnosed with Cushing’s syndrome 5 years ago at LASUTH, presented with worsening generalized body pains which had been gradual and continuous, causing limitation to movement, there was associated headache, photophobia, decline in vision, menstrual irregularities, marked weight gain with round moon facies, poor wound healing, polyuria, polydipsia, paresthesia on the hands, occasional frothiness of urine, fatigue, recurrent itchy skin rashes, palpitations. Her height-1.45m, weight-65kg, BMI–30.9kg/m2, WC-110cm. 24-hour Urine Free Cortisol (UFC): 806.06 (3.5-45ug/24hr). Fasting 8 am Cortisol: 558.94(240-618)nmol/l. Random serum cortisol: 501.42nmol/l (<276nmol/l). ACTH: <5.00 (0-46pg/ml). HbAIc: 6.94%. FBS: 7.07mmol/l, 2HPP: 9.57mmol/l. Pituitary MRI, chest, and abdominopelvic CT scan revealed no abnormalities. Lumbosacral MRI reviewed osteoporosis and moderate insufficiency fracture of L2 and L4 vertebral bodies. She was commenced on Metformin 500mg b.d & Alendronate 70mg weekly. CONCLUSION This report highlights the rare occurrence of Cushing’s syndrome in a female adolescent. Therefore, early detection and prompt intervention are crucial in management.
Scholarly article
Obijinmi B, Olopade OB, Odeniyi IA, Fasanmade OA. Cushing's syndrome in a female with short stature: a case report. Abstract 20. ACEN 2023 conference