Synthesis of Pyridine-fused Isothiazoles and 1,2-Oxathioles
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4-Lithio-Nt-butylpyridine-3-sulphonamide reacted with benzophenone and carbon dioxide respectively to give the corresponding intermediates which on appropriate treatment gave isothiazolo [5, 4-c] pyridin-3-one l, l-dioxides. Metalation of 2-and 4-(N, N-dialkylaminosulphonyl)pyridines with lithium diisopropylamide(LDA) gave anions which reacted with benzophenone to give carbinols which are thermally cyclised to give pyridine-fused isothiazoles and 1,2-oxathioles.
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesis
Alo, B. I., Familoni, O. B., Marsais, F., & Queguiner, G. Synthesis of Pyridine-fused Isothiazoles and l, 2-Oxathioles.