Evaluation of Antimicrobial properties of herbal ointments formulated with ethanolic extract of Acalypha wilkesiana

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dc.contributor.authorAzubuike, C.P.
dc.contributor.authorIgbokwe, N.
dc.contributor.authorElendu, N.
dc.contributor.authorEssien, G
dc.date.accessioned2020-02-24T11:09:30Z
dc.date.available2020-02-24T11:09:30Z
dc.date.issued2013
dc.descriptionStaff publicationsen_US
dc.description.abstractThe antimicrobial activity of ethanolic extract of dried fresh leaves of Acalypha wilkesiana and also those of the ointments formulated with the extract was evaluated. The preliminary in vitro antimicrobial activity of the extract at concentrations of 2.5mg/ml, 5mg/ml and 10mg/ml and those of the ointments was determined against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, Aspergillus flavus and Penicillium notatum using the agar cup plate method. Their Minimal Inhibitory Concentrations (MIC) were also determined by agar dilution method. Herbal ointments formulated by incorporating the ethanolic extract of Acalypha wilkesiana (10% w/w) into emulsifying ointment and simple ointment bases respectively and a commercial brand (Funbact A® cream) were evaluated for their in vitro antimicrobial efficacy and some physical properties. The zones of inhibition (mm) of the extract on the growth of the microorganisms were Escherichia coli (25.2 ±1.0), Staphylococcus aureus (28.1 ±0.5), Pseudomonas aeruginosa (32.4 ±0.4) and Candida albicans (22.4 ±1.3) but there were no zone of inhibition for Aspergillus flavus and Penicillium notatum. The MIC values of the extract against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans were 5.00, 1.25, 10.00 and 5.00mg/ml respectively. The formulation containing Acalypha wilkesiana extract in emulsifying ointment showed better antibacterial activity than the simple ointment. The herbal ointment also compared favourably with a commercial brand of Funbact A® cream. This study shows that ethanolic extract of Acalypha wilkesiana has both antibacterial and anti-candidal activity and also has high potential as antimicrobial agent when formulated as ointment for topical use.en_US
dc.identifier.citationAzubuike C. P., Igbokwe N. H., Essien, G. S. & Elendu N.J. (2013). Evaluation of Antimicrobial properties of herbal ointments formulated with ethanolic extract of Acalypha wilkesiana. Journal of Biological & Scientific Opinion, 1(2) 41-44.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7825
dc.language.isoenen_US
dc.relation.ispartofseriesJournal of Biological & Scientific Opinion;Vol.1(2)
dc.subjectAcalypha wilkesianaen_US
dc.subjectAntimicrobial propertiesen_US
dc.subjectEscherichia colien_US
dc.subjectStaphylococcus aureusen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectCandida albicansen_US
dc.subjectHerbal ointments.en_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleEvaluation of Antimicrobial properties of herbal ointments formulated with ethanolic extract of Acalypha wilkesianaen_US
dc.typeArticleen_US
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