Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

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dc.contributor.authorLi, Elizabeth
dc.contributor.authorGlasbey, JC
dc.contributor.authorNepogodiev, D
dc.contributor.authorSimoes, JFF
dc.contributor.authorOmar, OM
dc.contributor.authorVenn, ML
dc.contributor.authorEvans, JP
dc.contributor.authorFutaba, K
dc.contributor.authorKnowles, CH
dc.contributor.authorMinaya-Bravo, A
dc.contributor.authorMolan, H
dc.contributor.authorChand, M
dc.contributor.authorPockney, P
dc.contributor.authorDi Saverio, S
dc.contributor.authorSmart, N
dc.contributor.authorVallance, A
dc.contributor.authorVimalachandran, D
dc.contributor.authorWilkin, RJW
dc.contributor.authorSiaw-Acheampong, K
dc.contributor.authorBenson, RA
dc.contributor.authorBywater, E
dc.contributor.authorChaudhry, D
dc.contributor.authorDawson, BE
dc.contributor.authorGlasbey, JC
dc.contributor.author...
dc.contributor.authorAdamina, M
dc.contributor.authorArgawal, A
dc.contributor.authorAkkulak, M
dc.contributor.authorAlameer, E
dc.contributor.authorAlderson, D
dc.contributor.authorAlakoloko, F
dc.contributor.authoret, al
dc.date.accessioned2022-08-29T12:34:45Z
dc.date.available2022-08-29T12:34:45Z
dc.date.issued2020-11
dc.descriptionScholarly articleen_US
dc.description.abstractAim: This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic. Method: This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data. Results: From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58-14.06), postoperative SARS-CoV-2 (16.90, 7.86-36.38), male sex (2.46, 1.01-5.93), age >70 years (2.87, 1.32-6.20) and advanced cancer stage (3.43, 1.16-10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%). Conclusion: Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks.en_US
dc.identifier.citationCOVIDSurg Collaborative. Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic. Colorectal Dis. 2020 Nov 15:10.1111/codi.15431. doi: 10.1111/codi.15431. Epub ahead of print. PMID: 33191669; PMCID: PMC7753519.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11102
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectCanceren_US
dc.subjectcolon canceren_US
dc.subjectRectal canceren_US
dc.subjectsurgical oncologyen_US
dc.subjectResearch Subject Categories::MEDICINE::Surgeryen_US
dc.titleOutcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemicen_US
dc.typeArticleen_US
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