Helicobacter Pylori Strains From a Nigerian Cohort Show Divergent Antibiotic Resistance Rates and a Uniform Pathogenicity Profile

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dc.contributor.authorHarrison, U
dc.contributor.authorFowora, MA
dc.contributor.authorSeriki, AT
dc.contributor.authorLoell, E
dc.contributor.authorMuella, S
dc.contributor.authorUgo-Ijeh, M
dc.contributor.authorOnyekwere, CA
dc.contributor.authorLesi, OA
dc.contributor.authorOtegbayo, JA
dc.contributor.authorAkere, A
dc.contributor.authorNdububa, DA
dc.contributor.authorAdekanle, O
dc.contributor.authorAnomneze, EE
dc.contributor.authorAbdulkareem, FB
dc.contributor.authorAdeleye, IA
dc.contributor.authorCrispin, A
dc.contributor.authorRieder, G
dc.contributor.authorFischer, W
dc.contributor.authorSmith, S
dc.contributor.authorHaas, R
dc.date.accessioned2020-05-01T13:52:27Z
dc.date.available2020-05-01T13:52:27Z
dc.date.issued2017
dc.description.abstractAntibiotic resistance in Helicobacter pylori is a factor preventing its successful eradication. Particularly in developing countries, resistance against commonly used antibiotics is widespread. Here, we present an epidemiological study from Nigeria with 111 isolates. We analyzed the associated disease outcome, and performed a detailed characterization of these isolated strains with respect to their antibiotic susceptibility and their virulence characteristics. Furthermore, statistical analysis was performed on microbiological data as well as patient information and the results of the gastroenterological examination. We found that the variability concerning the production of virulence factors between strains was minimal, with 96.4% of isolates being CagA-positive and 92.8% producing detectable VacA levels. In addition, high frequency of bacterial resistance was observed for metronidazole (99.1%), followed by amoxicillin (33.3%), clarithromycin (14.4%) and tetracycline (4.5%). In conclusion, this study indicated that the infection rate of H. pylori infection within the cohort in the present study was surprisingly low (36.6%). Furthermore, an average gastric pathology was observed by histological grading and bacterial isolates showed a uniform pathogenicity profile while indicating divergent antibiotic resistance rates.en_US
dc.description.sponsorshipThis study was supported by Deutsche Forschungsgemeinschaft HA 2697/12-1,Deutsche Forschungsgemeinschaft HA 2697/18-1, Deutsches Zentrum fu ¨r Infektionsforschungen_US
dc.identifier.citationPLoS One . 2017 May 2;12(5):e0176454en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8260
dc.language.isoenen_US
dc.publisherPLoS Oneen_US
dc.titleHelicobacter Pylori Strains From a Nigerian Cohort Show Divergent Antibiotic Resistance Rates and a Uniform Pathogenicity Profileen_US
dc.typeArticleen_US
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