Inhibitory Action of Sulphated Chitin Derivatives on the Hydrolytic Activity of Thrombin
No Thumbnail Available
Date
1986-05
Authors
Okiei, W.O.
Nishimura, S.
Somorin, O.
Nishi, N.
Tokura, S.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Heparin, an anticoagulant polysaccharide, inhibits thrombin activity which plays the most important role in the blood clotting process. It is known to accelerate neutralization of thrombin activity instantaneously in the presence of antithrombin III (AT-III) (l). The thrombin-AT-III complex also inhibits Factor Xa moiety in the blood clotting system (2). In order to understand the exact mechanism of heparin action, the stepwise preparation of heparin-like materials should be investigated from the point of view of inhibition mechanism.
Description
Staff publications
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry , chitin , thrombin , inhibitory , Hydrolytic activity , chromogenic substrate
Citation
Okiei W., Nishimura S., Somorin O., Nishi N., Tokura S. (1986) Inhibitory Action of Sulphated Chitin Derivatives on the Hydrolytic Activity of Thrombin. In: Muzzarelli R., Jeuniaux C., Gooday G.W. (eds) Chitin in Nature and Technology.