Inhibitory Action of Sulphated Chitin Derivatives on the Hydrolytic Activity of Thrombin
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Heparin, an anticoagulant polysaccharide, inhibits thrombin activity which plays the most important role in the blood clotting process. It is known to accelerate neutralization of thrombin activity instantaneously in the presence of antithrombin III (AT-III) (l). The thrombin-AT-III complex also inhibits Factor Xa moiety in the blood clotting system (2). In order to understand the exact mechanism of heparin action, the stepwise preparation of heparin-like materials should be investigated from the point of view of inhibition mechanism.
Research Subject Categories::NATURAL SCIENCES::Chemistry , chitin , thrombin , inhibitory , Hydrolytic activity , chromogenic substrate
Okiei W., Nishimura S., Somorin O., Nishi N., Tokura S. (1986) Inhibitory Action of Sulphated Chitin Derivatives on the Hydrolytic Activity of Thrombin. In: Muzzarelli R., Jeuniaux C., Gooday G.W. (eds) Chitin in Nature and Technology.