Roll out of a successful antimicrobial stewardship programme in Lagos University Teaching Hospital Nigeria using the Global-Point Prevalence Survey

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dc.contributor.authorOshun, P.O.
dc.contributor.authorRoberts, A.A.
dc.contributor.authorOsuagwu, C.S.
dc.contributor.authorAkintan, P.E.
dc.contributor.authorFajolu, I.B.
dc.contributor.authorOla-Bello, O.I.
dc.contributor.authorOdukoya, O.O.
dc.contributor.authorAkodu, B.
dc.contributor.authorOkunowo, A.A.
dc.contributor.authorVersporten, A.
dc.contributor.authorPauwels, I.
dc.contributor.authorGoosens, H.
dc.contributor.authorBusari, A.A.
dc.contributor.authorOlusanya, A.W.
dc.contributor.authorNwaiwu, O.
dc.contributor.authorTemiye, E.O.
dc.contributor.authorOsibogun, A.O.
dc.contributor.authorBode, C.O.
dc.contributor.authorAntimicrobial Stewardship Committee
dc.contributor.authorOduyebo, O.O.
dc.date.accessioned2022-01-21T13:56:21Z
dc.date.available2022-01-21T13:56:21Z
dc.date.issued2021
dc.descriptionScholarly articlesen_US
dc.description.abstractBackground: Antimicrobial resistance (AMR) has become a public health emergency with increasing rates and spread globally. Antimicrobial stewardship (AMS) has been advocated to reduce the burden of antimicrobial resistance, promote rational and appropriate use of antibiotics and improve clinical outcomes. Education and training are one of the AMS interventions to improve antimicrobial use. We present the roll out of a successful AMS programme with education and training using the Global-PPS as data collection tool to measure AMS interventions and impact. Methodology: This was a cross sectional study on the implementation of an AMS programme at the Lagos University Teaching Hospital. Global PPS was conducted in 2015 to collect baseline data which was used to identify targets for quality improvement in AMS and was repeated in 2017 and 2018 to measure impact of AMS interventions. AMS interventions included education, feedback of Global-PPS result and writing of the hospital- wide antibiotic policy based on the baseline data. Results: Out of the 746 inpatients surveyed, 476 (68.3%) had received at least one antimicrobial on the days of Global-PPS. The antimicrobial prescribing rates reduced significantly over the three time periods. In 2015, 82.5% were placed on antimicrobials, 65.5% in 2017 and 51.1% in 2018 (p<0.00001). The documentation of indication for treatment significantly improved from 53.4% in 2015 to 97.2% in 2018 (p<0.0001). Stop review date also significantly improved from 28.7% to 70.2% in 2018 (p<0.00001). Surgical prophylaxis for more than 24 hours reduced significantly from 93.3% in 2015 to 65.7% in 2018 (p=0.002) even though the prevalence was still high. The three most commonly administered antimicrobial groups were third generation cephalosporins, imidazole derivatives and quinolones. The most commonly prescribed antibiotics for surgical prophylaxis were ceftriaxone and metronidazole in 2015 and ceftriaxone in 2017. Conclusion: The use of education and training as AMS intervention in a limited resource setting clearly made impact on antimicrobial prescribing patterns in the hospital. Global-PPS is useful to set quality improvement targets and for monitoring, evaluation and surveillance of an AMS programme.en_US
dc.identifier.citationOshun, P.O. Roberts, A.A. Osuagwu, C.S. Akintan, P.E. Fajolu, I.B. Ola-Bello, O.I. Odukoya, O.O. Akodu, B. Okunowo, A.A. Versporten, A. Pauwels, I. Goosens, H. Busari, A.A. Olusanya, A.W. Nwaiwu, O. Temiye, E.O. Osibogun, A.O. Bode, C.O. Antimicrobial Stewardship Committee Oduyebo, O.O. (2021). Roll out of a successful antimicrobial stewardship programme in Lagos University Teaching Hospital Nigeria using the Global-Point Prevalence Survey. African Journal of Clinical and Experimental Microbiology, 22 (2): 260 - 272.en_US
dc.identifier.issn1595-689X
dc.identifier.otherhttps://dx.doi.org/10.4314/ajcem.v22i2.19
dc.identifier.urihttps://www.afrjcem.org
dc.identifier.uri. https://www.ajol.info/index.php/ajcem
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10653
dc.language.isoenen_US
dc.publisherAfrican Journal of Clinical and Experimental Microbiologyen_US
dc.relation.ispartofseriesAfrican Journal of Clinical and Experimental Microbiology;22(2)
dc.subjectAntibioticen_US
dc.subjectStewardshipen_US
dc.subjectResistanceen_US
dc.subjectEducationen_US
dc.subjectGlobal-PPSen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleRoll out of a successful antimicrobial stewardship programme in Lagos University Teaching Hospital Nigeria using the Global-Point Prevalence Surveyen_US
dc.typeArticleen_US
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