Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry

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dc.contributor.authorJackson, A.M.
dc.contributor.authorPetrie, M.C.
dc.contributor.authorFrogoudaki, A.
dc.contributor.authorLaroche, C.
dc.contributor.authorGustafsson, F.
dc.contributor.authorIbrahim, B.
dc.contributor.authorMebazaa, A.
dc.contributor.authorJohnson, M.R.
dc.contributor.authorSeferovic, P.M.
dc.contributor.authorRegitz-Zagrosek, V.
dc.contributor.authorMbakwem, A.
dc.contributor.authorBöhm, M.
dc.contributor.authorPrameswari, H.S.
dc.contributor.authorFouad, D.A.
dc.contributor.authorGoland, S.
dc.contributor.authorDamasceno, A.
dc.contributor.authorKaraye, K.
dc.contributor.authorFarhan, H.A.
dc.contributor.authorHamdan, R.
dc.contributor.authorMaggioni, A.P.
dc.contributor.authorSliwa, K.
dc.contributor.authorBauersachs, J.
dc.contributor.authorvan der Meer, P.
dc.contributor.authorPPCM Investigators Group
dc.date.accessioned2021-12-07T10:09:09Z
dc.date.available2021-12-07T10:09:09Z
dc.date.issued2021-06-11
dc.descriptionScholarly articlesen_US
dc.description.abstractAims: Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy. Methods and results: The European Society of Cardiology EURObservational Research Programme PPCM Registry enrolled women with PPCM from 2012-2018. Three groups were examined: (i) women without hypertension (PPCM-noHTN); (ii) women with hypertension but without pre-eclampsia (PPCM-HTN); (iii) women with pre-eclampsia (PPCM-PE). Maternal (6-month) and neonatal outcomes were compared. Of 735 women included, 452 (61.5%) had PPCM-noHTN, 99 (13.5%) had PPCM-HTN and 184 (25.0%) had PPCM-PE. Compared to women with PPCM-noHTN, women with PPCM-PE had more severe symptoms (New York Heart Association class IV in 44.4% vs. 29.9%, P < 0.001), more frequent signs of heart failure (pulmonary rales in 70.7% vs. 55.4%, P = 0.002), a higher baseline left ventricular ejection fraction (LVEF) (32.7% vs. 30.7%, P = 0.005) and a smaller left ventricular end-diastolic diameter (57.4 ± 6.7 mm vs. 59.8 ± 8.1 mm, P = 0.001). There were no differences in the frequencies of death from any cause, rehospitalization for any cause, stroke, or thromboembolic events. Compared to women with PPCM-noHTN, women with PPCM-PE had a greater likelihood of left ventricular recovery (LVEF ≥ 50%) (adjusted odds ratio 2.08, 95% confidence interval 1.21-3.57) and an adverse neonatal outcome (composite of termination, miscarriage, low birth weight or neonatal death) (adjusted odds ratio 2.84, 95% confidence interval 1.66-4.87). Conclusion: Differences exist in phenotype, recovery of cardiac function and neonatal outcomes according to hypertensive status in women with PPCM.en_US
dc.identifier.citationJackson AM, Petrie MC, Frogoudaki A, Laroche C, Gustafsson F, Ibrahim B, Mebazaa A, Johnson MR, Seferovic PM, Regitz-Zagrosek V, Mbakwem A, Böhm M, Prameswari HS, Fouad DA, Goland S, Damasceno A, Karaye K, Farhan HA, Hamdan R, Maggioni AP, Sliwa K, Bauersachs J, van der Meer P. Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry. Eur J Heart Fail. 2021 Jun 11;. doi: 10.1002/ejhf.2264. [Epub ahead of print] PubMed PMID: 34114268.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9784
dc.language.isoenen_US
dc.publisherEur J Heart Failen_US
dc.subjectHeart failureen_US
dc.subjectHypertensionen_US
dc.subjectPeripartum cardiomyopathyen_US
dc.subjectPre-eclampsiaen_US
dc.subjectPregnancyen_US
dc.subjectResearch Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseasesen_US
dc.titleHypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registryen_US
dc.typeArticleen_US
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