Relationship between gestational diabetes mellitus and incidence of post-delivery dysglycaemia
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Date
2022-11
Authors
Udo, C
Olopade, O.B
Odeniyi, I.A
Fasanmade, O.A
Journal Title
Journal ISSN
Volume Title
Publisher
Bioscientifica
Abstract
Background
Gestational diabetes mellitus (GDM) is defined as glucose intolerance resulting in
hyperglycaemia of variable severity, with onset or first recognition during
pregnancy. GDM is a risk factor for dysglycaemia in later life. The objective of
the study was to determine the impact of GDM on glucose tolerance in the short
term post-delivery in a cohort of women who attended the Lagos University
Teaching Hospital (LUTH)
Study Design
This was a prospective observational study.
Methods
One hundred and twenty-eight pregnant women who attended LUTH antenatal clinics
and who had no history of pre-gestational glucose intolerance were recruited in the first
trimester of pregnancy. Pertinent data were collected via a questionnaire. The
participants underwent a 75g oral glucose tolerance test (OGTT) at 24-28 weeks
gestational age. Venous plasma glucose was measured viathe glucose oxidase method.
GDM was diagnosed using the World Health Organization (WHO) 2013 criteria. The
participants were followed up and OGTT repeated at 6-12 weeks post-delivery.
Statistical Analysis
Descriptive statistics were presented using mean and standard deviation. P-value
%0.05 was considered statistically significant.
Results
Among the participants with GDM, the incidence rate of dysglycaemia at 6-12 weeks
post-delivery, was 333 per 1000 person-years. Impaired glucose tolerance (IGT) was
the most common (77.8%) dysglycaemia observed. Presence of hypertension
(PZ0.004) and use of insulin during pregnancy (PZ0.024) were significantly
associated with post-delivery dysglycaemia.
Conclusions
GDM had a significant impact on the incidence of dysglycaemia in the short-term, 6-
12 weeks post-delivery, in women who accessed care at LUTH. Hypertension and
the requirement of insulin for glucose control increased the likelihood of abnormal
glucose metabolism following delivery, in a pregnancy complicated by GDM.
Keywords: Gestational diabetes mellitus, post-delivery dysglycaemia, Lagos
Description
Conference paper
Keywords
Gestational diabetes mellitus , post-delivery dysglycaemia , Pregnancy , Lagos University Teaching Hospital (LUTH) , Research Subject Categories::MEDICINE
Citation
Udo C, Olopade O, Odeniyi I, Fasanmade O. Relationship between gestational diabetes mellitus and incidence of post-delivery dysglycaemia. Endocrine Abstracts 2022; 86:P231