Comparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic rats

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dc.contributor.authorLawal, S.K
dc.contributor.authorAdeniji, A.A
dc.contributor.authorSulaiman, S.O
dc.contributor.authorAkajewole, M.M
dc.contributor.authorBuhari, M.O
dc.contributor.authorOsinubi, A.A
dc.date.accessioned2022-01-14T08:56:49Z
dc.date.available2022-01-14T08:56:49Z
dc.date.issued2019
dc.descriptionScholarly articlesen_US
dc.description.abstractBackground: Oral hypoglycemic agents use during pregnancy was assumed to cause fetal macrosomia and skeletal deformities, and maternal complications due to significant transfer across placenta or ineffective control of blood glucose. Objective: This study investigated effects of insulin, metformin and glibenclamide on maternal blood glucose; and fetal crown-rump length, gross malformation and pancreatic histology in pregnant streptozotocin-induced diabetic rats. Methods: Twenty-five pregnant rats of groups 1 to 5 as normal and diabetic controls; and diabetic treated with insulin, metformin and glibenclamide were used. Experimental GDM was induced using 45 and 35mg/Kgbw of intraperitoneal streptozotocin. Results: Metformin, Insulin and Glibenclamide significantly reduced maternal glucose by 140.6mg/dL, 103.2mg/dL and 98.54mg/dl; respectively and showed islets with regular interlobular ducts, islets with some irregular interlobular ducts, and islets with many irregular interlobular ducts in histological fetal pancreatic photomicrographs respectively. This depicts metformin having highest ameliorative effect. There were no significant differences in maternal and fetal body weights, maternal blood glucose between diabetic groups, and fetal gross examination. Conclusion: At the doses used in this research, metformin and glibenclamide showed no adverse effects on maternal and fetal features in the treatment of GDM. Thus, they can be used as safe and inexpensive alternatives to insulin.en_US
dc.identifier.citationLawal SK, Adeniji AA, Sulaiman SO, Akajewole MM, Buhari MO, & Osinubi AA. (2019). Comparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic rats. African Health Sciences, 19(3):2491-2504. DOI: 10.4314/ahs.v19i3.25.en_US
dc.identifier.issn1680-6905 (print); 1729-0503 (web)
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10349
dc.language.isoenen_US
dc.publisherAfrican Health Sciences, Makerere University Medical School (Uganda)en_US
dc.relation.ispartofseries19;3
dc.subjectGestational diabetes mellitusen_US
dc.subjectOral hypoglycemic agentsen_US
dc.subjectBlood glucoseen_US
dc.subjectFetal malformationen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleComparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US
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