Synthesis of 4H‐3,3a‐dihydrothiazolo[4,3‐b]quinazolines
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Regiospecific synthesis of 4H‐3,3a‐dihydrothiazolo[4,3‐b]quinazolines and 7‐methyl‐4H‐3,3a‐dihydrothiazolo[4,3‐b]quinazolines IVa and IVb is described. The N‐substituted thiazolidinecarboxylic acids Ia and Ib were converted to the corresponding acid chlorides, IIa and IIb but neither reacted with silver trifluoromethanesulphonate. The carboxylic acids Ic and Id were however, decarboxylated to the corresponding iminium ions using phosphorus oxychloride and these afforded the nitroamines IIIa and IIIb. Reductive cyclisation led to the quinazolines IVa and IVb.
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesis , Chemistry , carboxylic acids Ic , quinazolines IVa , Hiazolidinecarboxylic acids Ia and Ib
Adegoke, E. A., Alo, B. I., and Familoni, O. B. (1987). Synthesis of 4H‐3, 3a‐dihydrothiazolo [4, 3‐b] quinazolines. Journal of heterocyclic chemistry, Vol.24(1), 107-110pp.