A systematic review and meta-analysis of hydroartemisinin-piperaquine versus sulphadoxine-pyrimethamine for malaria prevention in pregnancy

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dc.contributor.authorOlaleye, A
dc.contributor.authorOkusanya, BO
dc.contributor.authorOduwole, O
dc.contributor.authorEsu, E
dc.contributor.authorMeremikwu, M
dc.date.accessioned2022-01-19T11:27:59Z
dc.date.available2022-01-19T11:27:59Z
dc.date.issued2019
dc.descriptionScholarly articlesen_US
dc.description.abstractBackground: Intermittent preventive treatment (IPT) with sulphadoxine-pyrimethamine (SP) is recommended for preventing maternal and fetal effects of malaria in pregnancy. Increasing parasite resistance to SP has necessitated the search for an alternative medication. Objective: To compare dihydroartemisinin-piperaquine (DP) and sulphadoxine-pyrimethamine in preventing malaria during pregnancy. Search strategy: Databases including CENTRAL, MEDLINE, and ICTRP were searched until August 2018. Selection criteria: Randomized and quasi-randomized controlled trials that compared DP with SP given to pregnant women to prevent adverse maternal or fetal effects of malaria were included. Data collection and analysis: Quality of evidence was determined with GRADE criteria. Effectiveness measures were calculated using odds ratios at 95% confidence intervals. Results: Three randomized controlled trials were included. Compared with IPT-SP, moderate certainty evidence indicated that women who received IPT-DP had significantly lower risks of clinical malaria during pregnancy. High certainty evidence showed intermittent screening and treatment with DP did not reduce placental malaria or maternal parasitemia at delivery. Effect of DP on low birth weight and adverse birth outcomes was minimal. Conclusions: Moderate certainty evidence suggests that IPT-DP may reduce maternal and placental malaria compared with IPT-SP, and monthly DP is more effective than SP in reducing placental malaria.en_US
dc.identifier.citationOlaleye A, Okusanya BO, Oduwole O, Esu E, Meremikwu M. A systematic review and meta-analysis of ihydroartemisinin-piperaquine versus sulphadoxine-pyrimethamine for malaria prevention in pregnancy. Int J Gynaecol Obstet. 2019;146(1):43-55.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10532
dc.language.isoenen_US
dc.relation.ispartofseriesProf. Martin Meremikwu;
dc.subjectSulphadoxine-pyrimethamineen_US
dc.subjectPregnancyen_US
dc.subjectMalariaen_US
dc.subjectIntermittent screening and treatmenten_US
dc.subjectIntermittent preventive treatmenten_US
dc.subjectArtemisinin-based combination therapyen_US
dc.subjectResearch Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseases::Obstetrics and gynaecologyen_US
dc.titleA systematic review and meta-analysis of hydroartemisinin-piperaquine versus sulphadoxine-pyrimethamine for malaria prevention in pregnancyen_US
dc.typeOtheren_US
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