A Comparative Bioavailability Study of Paracetamol Tablet and Suppository Formulations
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West Afr. J. Pharm.
The bioavailability of 2 different paracetamol suppository formulations were compared with that of a standard paracetamol tablet formulation in 10 healthy adult volunteers. Paracetamol was rapidly and completely absorbed from both the tablet and suppository forms. The rate of absorption was faster from the tablet form than the suppository form. Although formulation C had a slower initial release of paracetamol than formulation A, its relative bioavailability was greater. The effective concentration of paracetamol in the blood was rapidly attained and maintained for about 6 hours.
paracetamol , suppository , bioavailability , Blood , Research Subject Categories::PHARMACY
Taylor, O., Igwilo, C.I., Silva, B.O., Coker, H.A.B., Soremekun, R. (1997). A Comparative Bioavailability Study of Paracetamol Tablet and Suppository Formulations. West Afr. J. Pharm., 11(2), 54-58