Thyroid autoimmunity in pregnant Nigerians
| dc.contributor.author | Kayode, O. | |
| dc.contributor.author | Odeniyi, I. | |
| dc.contributor.author | Iwuala, S. | |
| dc.contributor.author | Olopade, O.B. | |
| dc.contributor.author | Fasanmade, O. | |
| dc.contributor.author | Ohwovoriole, A. | |
| dc.date.accessioned | 2019-11-08T15:18:35Z | |
| dc.date.available | 2019-11-08T15:18:35Z | |
| dc.date.issued | 2015-09 | |
| dc.description | Staff publications | en_US |
| dc.description.abstract | CONTEXT: Thyroid autoimmunity is a recognized disorder in pregnancy and is associated with a number of adverse pregnancy outcomes. AIM: This study set out to determine the relationship between pregnancy and thyroid autoimmunity in Nigerian women. SETTINGS AND DESIGN: This was an analytical cross-sectional study carried out in a tertiary hospital in South Western Nigeria with a total study population of 108 pregnant and 52 nonpregnant women. SUBJECTS AND METHODS: Serum thyroid stimulating hormone, free thyroxine and thyroid peroxidase antibodies (TPO-Ab) were quantitatively determined using enzyme linked immuno-assays. Pregnant women were grouped into three categories (<14 weeks, 14-28 weeks and > 28 weeks). The relationship between pregnancy and thyroid autoimmunity was determined using Spearman correlation. Analysis of variance was used in comparison of means, Chi-square test used in analyzing proportions while P ≤ 0.05 was considered as significant. RESULTS: The mean age of the pregnant women was 30.4 ± 6.0 years while the mean gestational age of all pregnant women was 20.6 ± 9.6 weeks. The mean TPO-Ab of 11.58 IU/ml in the pregnant was significantly higher than that of the controls of 7.23 IU/ml (P < 0.001). Out of 108 pregnant women, 27 (25%) had elevated TPO-Ab as against about 2% of the nonpregnant women levels P < 0.001. The number of pregnant women with elevated TPO-Ab levels decreased from 33.3% in the first group to 25.6% and 15.2% in the second and third groups. CONCLUSION: Thyroid autoimmunity expressed by the presence of TPO-Ab is high among pregnant Nigerian women and the frequency of autoimmunity appears to decline with advancing gestational age. | en_US |
| dc.identifier.citation | Kayode OO, Odeniyi IA, Iwuala S, Olopade OB, Fasanmade OA, Ohwovoriole AE. Thyroid autoimmunity in pregnant Nigerians. Indian J Endocrinol Metab. 2015 Sep-Oct;19(5):620-4. | en_US |
| dc.identifier.issn | 2230-9500, 2230-8210 | |
| dc.identifier.other | doi: 10.4103/2230-8210.163178 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/6789 | |
| dc.language.iso | en | en_US |
| dc.publisher | Medknow | en_US |
| dc.relation.ispartofseries | Indian J Endocrinol Metab.;Vol.19(5) | |
| dc.subject | Autoimmunity | en_US |
| dc.subject | Pregnancy | en_US |
| dc.subject | Thyroid | en_US |
| dc.subject | Research Subject Categories::MEDICINE | en_US |
| dc.title | Thyroid autoimmunity in pregnant Nigerians | en_US |
| dc.type | Article | en_US |