Comparison of low dose and standard dose adrenocorticotropin stimulation tests in healthy Nigerians

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dc.contributor.authorOdeniyi, I.A
dc.contributor.authorFasanmade, O.A
dc.contributor.authorAjala, M.O
dc.contributor.authorOhwovoriole, A.E
dc.date.accessioned2020-01-07T08:31:17Z
dc.date.available2020-01-07T08:31:17Z
dc.date.issued2010
dc.descriptionStaff publicationsen_US
dc.description.abstractHypothalamo-pituitary-adrenal (HPA) axis dysfunction is a potentially life-threatening condition. It is of paramount importance that safe, reliable diagnostic tests be available to identify patients at risk for adrenal insufficiency. The 250 microg Adrenocorticotropic hormone (ACTH) stimulation test is commonly used to assess adrenocortical function. The 250 microg dose is supraphysiological, therefore several investigators, over the years, have used 1 microg ACTH stimulation test to assess adrenocortical function. The aim of the study was to compare the response of healthy adult Nigerian subjects to the 250 microg and 1 microg ACTH tests. Ten healthy subjects, five males and five females, aged between 20-60 years, (mean, 38.7 years) participated in this study. They all had normal medical histories and physical examinations, were nonsmokers, and had never received any type of glucocorticoid therapy. Serum chemistries, full blood counts, erythrocyte sedimentation rate, were all within normal limits. Both low dose ACTH test and standard dose ACTH test were performed on the 10 subjects in a randomized order on different days.There was no statistically significant difference in mean serum cortisol levels between the two test doses at 30 minutes (928.4 vs 929.8 nmol/L). There was a strong correlation between 30-minute cortisol responses to 1 microg and 250 microg ACTH stimulation tests, r = 0.999; p < 0.001. In agreement with other published data, our study confirms that 1 microg ACTH stimulates adrenocortical secretion in normal subjects in the period 30 minutes post injection comparable to 250 microg ACTH testing.en_US
dc.identifier.citationOdeniyi IA, Fasanmade OA, Ajala MO, Ohwovoriole AE. Comparison of low dose and standard dose adrenocorticotropin stimulation tests in healthy Nigerians. African Journal of Medicine and Medical Sciences, 01 Jun 2010, 39(2):113-118en_US
dc.identifier.issn03093913
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7299
dc.language.isoenen_US
dc.publisherUniversity College Hospitalen_US
dc.relation.ispartofseriesAfrican Journal of Medicine and Medical Sciences;Vol.39(2)
dc.subjectadrenocorticotropic hormone (ACTH)en_US
dc.subjectCortisolen_US
dc.subjectLow dose testen_US
dc.subjectStandard dose testen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmaceuticsen_US
dc.titleComparison of low dose and standard dose adrenocorticotropin stimulation tests in healthy Nigeriansen_US
dc.typeArticleen_US
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