Hypogonadism and subnormal total testosterone levels in men with type 2 diabetes mellitus
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Date
2011
Authors
Ogbera, A.O.
Chinenye, S.
Fasanmade, O.
Ajala, W.
Journal Title
Journal ISSN
Volume Title
Publisher
College of Physicians and Surgeons Pakistan
Abstract
Objective: To determine the frequency of testosterone deficiency syndrome (TDS) in men with type 2 (DM).
Study Design: A cross-sectional study.
Place and Duration of Study: The Gbagada General Hospital, Gbagada Lagos, Nigeria, from December 2009 to May 2010.
Methodology: A total of 203 men with type 2 DM aged 30-86 years were evaluated for TDS by a combination of positive ADAM (androgen deficiency in the ageing male) scores and subnormal total testosterone levels. Mild testosterone deficiency referred to total testosterone (TT) levels of 8-12 nmol/L with symptoms of hypogonadism and severe testosterone deficiency referred to TT levels < 8 nmol/L with or without hypogonadal symptoms.
Results: Mild and severe TDS were present in 18.3% and 17% respectively of the study subjects. Commonly occurring clinical parameters of the TDS were erectile dysfunction and loss of libido which were documented in 63% and 60% respectively in the study subjects. The majority of clinical features of the TDS were comparable in men with and without the TDS.
Conclusion: About a third of men with type 2 DM had the TDS. The majority of the symptoms of hypogonadism are largely non-specific and their occurrence is comparable in men with and without low testosterone levels; thus, underscoring the need to have testosterone levels determined in men presenting with such symptoms.
Description
Keywords
Hypogonadism , Type 2 diabetes mellitus , Total testosterone levels , Diabetes mellitus
Citation
Ogbera, A.O., Chinenye, S., Fasanmade, O., and Ajala, W. (2011). Hypogonadism and subnormal total testosterone levels in men with type 2 diabetes mellitus. Journal of the College of Physicians and Surgeons Pakistan, 21(9), 146-152.