CD4 count as a predictor of adrenocortical insufficiency in persons with human immunodeficiency virus infection: How useful?

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dc.contributor.authorOdeniyi, I.A.
dc.contributor.authorFasanmade, O.A.
dc.contributor.authorAjala, M.O.
dc.contributor.authorOhwovoriole, A.E.
dc.date.accessioned2019-11-08T15:57:48Z
dc.date.available2019-11-08T15:57:48Z
dc.date.issued2013
dc.descriptionStaff publicationsen_US
dc.description.abstractOBJECTIVE: To determine the usefulness of CD4 count in predicting adrenocortical insufficiency (AI) in persons with HIV infection. DESIGN: Experimental study involving people with HIV infection and healthy people. PARTICIPANTS: The participants were recruited from the Lagos University Teaching Hospital. Forty-three newly diagnosed, treatment naive persons with HIV (23 males and 20 females) and 70 (35 males and 35 females) HIV negative subjects completed the study. INTERVENTION: One microgram Synacthen(®) was given intravenously to stimulate the adrenal glands. MAIN OUTCOME MEASURES: Blood was collected for cortisol at 0 and 30 min after the injection of adrenocorticotropic hormone (ACTH) and CD4 count. RESULTS: Mean basal cortisol was 154.9 ± 27.2 nmol/L and 239.9 ± 31.6 nmol/L (P < 0.001); the 30-min post ACTH test, cortisol level was 354.8 ± 19.9 nmol/L and 870.9 ± 163.5 nmol/L (P < 0.001); the increment was 100.0 ± 17.2 nmol/L and 588.8 ± 143.4 nmol/L (P < 0.001) in HIV and healthy subject group; respectively. Using the diagnostic criteria for diagnosis of AI in this study, fifteen (34.8%) persons with HIV had AI. There was no significant correlation between basal cortisol levels and CD4 count in patients with HIV infection (r = -0.2, P = 0.198). There was no significant correlation between stimulated cortisol level and CD4 count in patients with HIV infection (r = -0.09, P = 0.516). CONCLUSION: CD4 count does not predict the presence or absence of AI. ACTH stimulation of the adrenal gland remains the acceptable standard.en_US
dc.identifier.citationOdeniyi IA, Fasanmade OA, Ajala MO, Ohwovoriole AE. CD4 count as a predictor of adrenocortical insufficiency in persons with human immunodeficiency virus infection: How useful? Indian J Endocr Metab 2013; 17:1012-7.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6798
dc.language.isoenen_US
dc.relation.ispartofseriesIndian J Endocr Metab;Vol.17
dc.subjectAdrenocorticotropic hormoneen_US
dc.subjectCD4 counten_US
dc.subjectCortisolen_US
dc.subjectHuman Immunodeficiency Virusen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleCD4 count as a predictor of adrenocortical insufficiency in persons with human immunodeficiency virus infection: How useful?en_US
dc.typeArticleen_US
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