Extraction and characterization of the gum exudate of Anacardium occidentale for its potential as an excipient in drug delivery systems

Simple item page
dc.contributor.authorOlogunagba, M.O.
dc.contributor.authorJain, S.
dc.contributor.authorThanki, K.
dc.contributor.authorSuresh, S.
dc.contributor.authorFurtado, S.
dc.contributor.authorAzubuike, C.P.
dc.contributor.authorSilva, B.O.
dc.date.accessioned2020-02-25T08:13:02Z
dc.date.available2020-02-25T08:13:02Z
dc.date.issued2017-08
dc.descriptionStaff publicationsen_US
dc.description.abstractNatural polymers are preferentially used over synthetics as excipients in formulation systems. Characterization of a polymer is essential to determine its suitability as an excipient. This study aimed at extraction and characterization of Anacardium occidentale (Anacardiaceae) gum for its potential as an excipient in drug delivery systems. Anacardium occidentale gum (AoG) sourced from South West Nigeria was extracted from the dried stem bark exudate gum using a modified established method. Physicochemical, pharmacognostical and solid state parameters were characterized. Extraction yield was high (72%w/w); it had desirable organoleptic properties, moisture content (9.32% ± 0.03), total ash values (2.00% ± 0.00), acidic pH (5.0), low swelling capacity (3.71 ± 0.04) swelling index (2.37 ± 0.073), hydrated to form gel (hydrogel). Phytochemical studies of AoG showed absence of tested bioactive substances; Magnesium ion was the predominant amongst its divalent metallic ions content, it did not contain hazardous lead ion. The FTIR spectrum established its polysaccharide nature as stretches of alkanes, alkynes, alcohols, phenols, phenyl, acetyl, carboxylic acids, carboxylate, ethers, aldehydes and ketones functional groups were observed, hence modifiable. Morphological structure revealed sharp irregular discrete particles with size range of 79.4 μm and 144 μm. Powder diffraction pattern showed the existence of two prominent peaks at 13.50 and 19.2 0 2 Theta, AoG thermal analysis showed that it is thermally stable. AoG had good and desirable physicochemical properties such as hydrogel formation which could be employed either as a matrix layer former or carrier agent in drug deliveryen_US
dc.identifier.citationOlogunagba M. O. , Jain S., Thanki K. , Suresh S., Furtado S., Azubuike C. P.& Olanrewaju S. B. (2017). Extraction and Characterization of the Gum Exudate of Anacardium occidentale for its potential as an Excipient in Drug Delivery Systems. Trop J Nat Prod Res, 1(2):76-83.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7844
dc.language.isoenen_US
dc.publisherNatural Product Research Group, University of Beninen_US
dc.relation.ispartofseriesTrop J Nat Prod Res,;Vol.1(2)
dc.subjectNatural Polymer Gumen_US
dc.subjectAnacardium occidentaleen_US
dc.subjectCharacterizationsen_US
dc.subjectExcipient Potentialsen_US
dc.subjectNovel Drug Deliveryen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleExtraction and characterization of the gum exudate of Anacardium occidentale for its potential as an excipient in drug delivery systemsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Article 24.pdf
Size:
677.49 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Pharmaceutics and Pharmaceutical Technology- Scholarly Publications