Histopathological and Immunohistochemical Characteristics of Breast Carcinomas in Uyo, Subtropical Region of Africa
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Date
2019
Authors
Tanimowo, MO
Abudu, EK
Udo, IA
Abdulkareem, FB
Journal Title
Journal ISSN
Volume Title
Publisher
Medical Journal of Zambia
Abstract
Background: There is a relative dearth of data for
immunohistochemical characteristics of breast
carcinomas in cancer registries of Nigeria and some
parts of Africa. A descriptive hospital based study,
done over a year, involving three hospitals in Uyo
rendering breast cancer care.
Objective: To determine the immunohisto
chemical-expression pattern of oestrogen receptor,
progesterone receptor, and human epidermal
receptor 2 and their relationship with
histopathological features of invasive breast
carcinomas in Uyo, Akwa Ibom State.
Materials and methods: Each specimen with an
accompanying completely filled coded proforma
form containing clinical characteristics of patients
with breast cancer was received at the
Histopathology Department for subsequent
histopathological and immunohistochemical
analysis.
Results: The age range for patients with breast
carcinoma was 23 -70 years with a mean age at
presentation of43.07 ± 11.19 years. Invasive ductal
carcinoma was the commonest histological type
accounting for 86.9 % of all breast cancer. Positivity
for oestrogen receptors, progesterone receptors and
Her-2 were seen in 18.0 %, 14.8 % and 32.8 % of
breast carcinomas respectively. Majority of breast
carcinomas were triple negative phenotype (62.3 %).
Conclusion: Majority of the invasive breast
carcinomas in our environment were triple negative
phenotype (62.3 %).
Description
Keywords
Histopathological, Immunohistochemical Characteristics, Breast cancer, Uyo.
Citation
Medical Journal of Zambia, Vol. 46 (2): 100 - 108 (2019)